NCT03780530

Brief Summary

this study aims to assess the efficacy and the safety of various cosmetic techniques (subcuticular, surgical glue, adhesive tapes) for perineal skin closure during mediolateral episiotomy repair

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
207

participants targeted

Target at P25-P50 for phase_3

Timeline
Completed

Started Jan 2019

Shorter than P25 for phase_3

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

December 16, 2018

Completed
3 days until next milestone

First Posted

Study publicly available on registry

December 19, 2018

Completed
13 days until next milestone

Study Start

First participant enrolled

January 1, 2019

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2019

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2019

Completed
Last Updated

December 20, 2018

Status Verified

December 1, 2018

Enrollment Period

9 months

First QC Date

December 16, 2018

Last Update Submit

December 18, 2018

Conditions

Outcome Measures

Primary Outcomes (2)

  • Short -term postpartum pain

    Post-operative perineal pain will be evaluated at 6 hrs after the procedure using visual analogue scale patient to choose a number from 0 to 10 that best describes their current pain. 0 would mean "no pain" and 10 would mean "worst possible pain

    six hours postpartum

  • Short -term postpartum pain

    Post-operative perineal pain will be evaluated at 10 days after the procedure using visual analogue scale patient to choose a number from 0 to 10 that best describes their current pain. 0 would mean "no pain" and 10 would mean "worst possible pain

    10 days postnatal

Study Arms (3)

subcuticular suturing

ACTIVE COMPARATOR
Procedure: subcuticular suturing

surgical glue

ACTIVE COMPARATOR
Procedure: Surgical glue

adhesive steri-strip tape

ACTIVE COMPARATOR
Procedure: adhesive steri-strip tape

Interventions

Those undergoing Subcuticular suturing of perineal skin using 910 polyglactin vicryl No 2/0 (EGYCRYL®).

subcuticular suturing
Surgical gluePROCEDURE

Those undergoing perineal skin closure using adhesive glue n-butyl-2-cyanoacrylate (Histoacryl®).

surgical glue

Those undergoing closure of perineal skin via Adhesive surgical water-resistant tape application. (3M® Transpore™ Surgical Tapes).

adhesive steri-strip tape

Eligibility Criteria

Age18 Years+
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Women aged above 18 yrs.
  • Primiparous.
  • Undergoing spontaneous vaginal delivery of a single full-term fetus.
  • Vertex presentation.
  • Having mediolateral episiotomy.

You may not qualify if:

  • Body mass index ≥ 35 kg/m2
  • Complicated delivery by any tears other than episiotomy or postpartum hemorrhage.
  • Any risk factor causing increased stretch of the perineum; Operative vaginal delivery, fetal macrosomia.
  • The use of epidural anesthesia.
  • Previous perineal surgeries, local infection or lesions.
  • Any medical condition that can cause excessive bleeding or impair wound healing; (cardiovascular disease, diabetes, anemia, coagulopathy, collagen disease or Immunosuppression).
  • Contraindication or Hypersensitivity to any of materials used in the study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

December 16, 2018

First Posted

December 19, 2018

Study Start

January 1, 2019

Primary Completion

October 1, 2019

Study Completion

December 1, 2019

Last Updated

December 20, 2018

Record last verified: 2018-12