Blood Parameters as a Predictor of Fever After Percutaneous Nephrolithotomy

NCT03774940 | Completed

• 1 other identifier: 2013/198
• Study Type: interventional
• Target: 519
• Locations: 1 country
• Sites: 1

Brief Summary

To investigate the relationship between neutrophil count, lymphocyte count, neutrophil-to-lymphocyte count ratio (NLR), and postoperative fever in patients undergoing percutaneous nephrolithotomy (PNL).

Conditions

Urinary Tract Infection Bacterial; Nephrolithiasis

Keywords

fever; bacteremia; lymphocytes; percutaneous nephrolithotomy; neutrophil-lymphocyte ratio

Outcome Measures

Primary Outcomes (4)

• White blood cell count

  white blood cell count

  preoperative

• Neutrophil count

  neutrophil count

  preoperative

• N/L

  ratio of neutrophil count to lymphocyte count

  preoperative

• Lymphocyte count

  Lymphocyte count

  preoperative

Study Arms (2)

fever

EXPERIMENTAL

patients that have fever after PNL

Diagnostic Test: peripheric blood count

No fever

ACTIVE COMPARATOR

Patients without fever after PNL

Diagnostic Test: peripheric blood count

Interventions

peripheric blood count DIAGNOSTIC_TEST

preoperative peripheric blood count

No fever; fever

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• underwent PNL operation
• preoperative white blood cell count between 4,000 and 12,000/µL

You may not qualify if:

• preoperative urinary system obstruction
• proliferation in preoperative and/or postoperative urine culture
• preoperative and/or postoperative blood transfusions
• a preoperative urinary diversion and/or intervention
• the presence of a postoperative residual stone
• the presence of malignancy,
• the presence of a hematologic disease.
• patients with postoperative complications graded as Clavien 2 and above

Sponsors & Collaborators

• TC Erciyes University: lead

Study Sites (1)

Erciyes University Faculty of Medicine Department of Urology

Kayseri, 38039, Turkey (Türkiye)

Location

Related Publications (21)

• Draga RO, Kok ET, Sorel MR, Bosch RJ, Lock TM. Percutaneous nephrolithotomy: factors associated with fever after the first postoperative day and systemic inflammatory response syndrome. J Endourol. 2009 Jun;23(6):921-7. doi: 10.1089/end.2009.0041.

  PMID: 19473071 BACKGROUND

• Cadeddu JA, Chen R, Bishoff J, Micali S, Kumar A, Moore RG, Kavoussi LR. Clinical significance of fever after percutaneous nephrolithotomy. Urology. 1998 Jul;52(1):48-50. doi: 10.1016/s0090-4295(98)00146-0.

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• Sharifi Aghdas F, Akhavizadegan H, Aryanpoor A, Inanloo H, Karbakhsh M. Fever after percutaneous nephrolithotomy: contributing factors. Surg Infect (Larchmt). 2006 Aug;7(4):367-71. doi: 10.1089/sur.2006.7.367.

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  PMID: 22912753 BACKGROUND

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  PMID: 17034608 BACKGROUND

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• Tang K, Liu H, Jiang K, Ye T, Yan L, Liu P, Xia D, Chen Z, Xu H, Ye Z. Predictive value of preoperative inflammatory response biomarkers for metabolic syndrome and post-PCNL systemic inflammatory response syndrome in patients with nephrolithiasis. Oncotarget. 2017 Aug 18;8(49):85612-85627. doi: 10.18632/oncotarget.20344. eCollection 2017 Oct 17.

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• Cetinkaya M, Buldu I, Kurt O, Inan R. Platelet-to-Lymphocyte Ratio: A New Factor for Predicting Systemic Inflammatory Response Syndrome after Percutaneous Nephrolithotomy. Urol J. 2017 Aug 29;14(5):4089-4093.

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MeSH Terms

Conditions

Nephrolithiasis; Fever; Bacteremia

Condition Hierarchy (Ancestors)

Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Urolithiasis; Male Urogenital Diseases; Body Temperature Changes; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Bacterial Infections; Bacterial Infections and Mycoses; Infections; Sepsis; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes

Study Officials

• Abdullah Demirtas, MD

  Erciyes University Faculty of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc.Prof.

Study Record Dates

• First Submitted: December 9, 2018
• First Posted: December 13, 2018
• Study Start: January 1, 2005
• Primary Completion: December 1, 2013
• Study Completion: January 31, 2014
• Last Updated: December 13, 2018

Record last verified: 2018-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)