Clinicopathological Importance of Colorectal Medullary Carcinoma: Retrospective Cohort Study

NCT03774862 | Completed

• 1 other identifier: VKVAmericanH
• Study Type: observational
• Target: 13
• Locations: 0 countries
• Sites: N/A

Brief Summary

Medullary carcinoma (MC) is a rare tumor with solid growth pattern without glandular differentiation and constitute less than 1% of colorectal cancer. Lymph node positivity and distant organ metastasis were reported to be lower than other poorly differentiated adenocarcinomas. Therefore, the diagnosis of MC is pathologically important in terms of follow-up and treatment. MC is commonly localized in the right colon, has a large tumor size, and is mostly diagnosed in the T4 stage. As MC most likely have defects in DNA MMR, the correct pathological diagnosis is important for the postoperative treatment and the prognosis of the patients.

Conditions

Colorectal Medullary Carcinoma

Keywords

Medullary carcinoma; Colorectal cancer; Microsatellite instability

Outcome Measures

Primary Outcomes (1)

• Overall survival of medullar colorectal carcinomas

  7 years

Study Arms (2)

Medullary carcinoma of colorectal cancers

non-medullary carcinomas of the colorectal cancers

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

427 patients with colorectal cancer who were underwent surgery between January 2011 and December 2017, were evaluated retrospectively into 2 groups as MC (n:13) and non-MC (n:414) in terms of demographic characteristics, pathological data and oncological outcomes.

You may qualify if:

• colorectal cancer diagnosis, medullary carcinoma

You may not qualify if:

• none

Sponsors & Collaborators

• V.K.V. American Hospital, Istanbul: lead

MeSH Terms

Conditions

Carcinoma, Medullary; Colorectal Neoplasms; Microsatellite Instability

Condition Hierarchy (Ancestors)

Carcinoma, Neuroendocrine; Neuroendocrine Tumors; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms, Ductal, Lobular, and Medullary; Neoplasms, Nerve Tissue; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases; Genomic Instability; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: General surgery specialist

Study Record Dates

• First Submitted: September 5, 2018
• First Posted: December 13, 2018
• Study Start: January 1, 2011
• Primary Completion: December 31, 2017
• Study Completion: August 1, 2018
• Last Updated: December 13, 2018

Record last verified: 2018-12

Data Sharing

• IPD Sharing: Will not share