MRI Maker of Perioperative Neurocognitive Disorder
MRIPND
MRI Marker of Postoperative Delirium and Delayed Neurocognitive Recovery
1 other identifier
observational
100
1 country
1
Brief Summary
Periperative neurocognitive disorder(PND) is consistently associated with increased morbidity and mortality, but its mechanisms remain unclear. Moreover, valid biomarkers for the prediction or diagnosis of the development of delayed neurocognitive recovery in aged patients have not been identified so far. The purpose of this study is trying to find the functional MRI marker of PND.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Dec 2018
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 10, 2018
CompletedFirst Posted
Study publicly available on registry
December 12, 2018
CompletedStudy Start
First participant enrolled
December 12, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 30, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
July 30, 2020
CompletedDecember 13, 2018
December 1, 2018
1 year
December 10, 2018
December 11, 2018
Conditions
Outcome Measures
Primary Outcomes (1)
MRI markers of PND before 7th day after surgery
To analysis the association of volume of hippocampus measured by MRI and the occurrence of PND identified at the 7th day after surgery
From the day before surgery to the 7th day after surgery
Secondary Outcomes (1)
MRI markers of PND before 12 month after surgery
From the 7th day after surgery to 12 month after surgery
Eligibility Criteria
Patients elder than 60 years old elective to undergo lower limb surgery and conform to the including criteria would be recruited.
You may qualify if:
- Age ≥ 60 years
- Spoke proficient Chinese
- Selected to lower limb osteopathic surgery
- Informed consent signed by the patient
- Underwent general anesthesia
You may not qualify if:
- Existing cerebral disease, or have a history of neurological and psychiatric diseases including AD, stroke, and psychosis
- Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24
- Several audition or vision disorder
- With standard contraindications to MRI examinations
- Unwillingness to comply with the protocol or procedures.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- RenJi Hospitallead
Study Sites (1)
Renji Hospital
Shanghai, Shanghai Municipality, 200127, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
qi lu, Dr.
Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
December 10, 2018
First Posted
December 12, 2018
Study Start
December 12, 2018
Primary Completion
December 30, 2019
Study Completion
July 30, 2020
Last Updated
December 13, 2018
Record last verified: 2018-12