Factors Affecting Newborn Body Composition and Later Health in Helsinki Birth Cohort 2018-2022

NCT03765684 | Active Not Recruiting

• 1 other identifier: HUS/180/2018, HUS/512/2019
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

In Helsinki Birth Cohort 2018-2022 a large, longitudinal and well-phenotyped birth cohort of infants and their parents will be established. Mothers, fathers/spouses and their children in Helsinki and Uusimaa Hospital District are recruited in the study and newborn composition of the children born in Helsinki Women's Hospital will be measured. Data on maternal and paternal diet quality, physical activity and depression during and after pregnancy will be collected and data from the hospital and national registers will be collected. Health of offspring and parents will be followed during their later life.

Conditions

Offspring, Adult; Lifestyle; Obesity, Childhood; Pregnancy Related; Child Development

Outcome Measures

Primary Outcomes (1)

• Neonatal body fat %

  Measured with PEA POD Cosmed® Infant Body Composition Assessment system

  Within 72 hours of birth

Secondary Outcomes (4)

• Newborn weight

  Within 2 hours of birth

• Newborn height

  Within 2 hours of birth

• ASQ-3

  3 months, 1 year and 2 years of age

• ITSEA

  3 months, 1 year and 2 years of age

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The first phase of the Helsinki Birth Cohort (HeBiCo) will be constituted of all the neonates whose body composition at birth can be obtained at Helsinki Women's Hospital, and whose mothers and fathers/spouses fill out the questionnaires after delivery (background, food frequency (FFQ), and depression questionnaires (EPDS, CES-D)). In the second phase of HeBiCo, participants will be recruited any time during pregnancy and also at postnatal ward after delivery.

You may qualify if:

• Mothers, fathers/spouses and offspring in Helsinki and Uusimaa Hospital District.

You may not qualify if:

• Inability to communicate in Finnish language

Sponsors & Collaborators

• Helsinki University Central Hospital: lead
• University of Helsinki: collaborator
• Finnish Institute for Health and Welfare: collaborator
• UKK Institute: collaborator

Study Sites (1)

HUS Women's hospital, Helsinki Unversity Hospital

Helsinki, 00029, Finland

Location

Biospecimen

Retention: SAMPLES WITH DNA

Maternal and umbilical cord blood sample is collected and stored for later analysis

MeSH Terms

Conditions

Pediatric Obesity

Condition Hierarchy (Ancestors)

Obesity; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Saila SB Koivusalo

  Helsinki University Hospital, Women's Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor, Development Manager

Study Record Dates

• First Submitted: December 3, 2018
• First Posted: December 5, 2018
• Study Start: December 1, 2018
• Primary Completion: December 31, 2022
• Study Completion (Estimated): December 31, 2026
• Last Updated: March 12, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

FI (1)