The Effect of the ALDH2 Gene Polymorphism on the Propofol Potency for Inducing Loss of Consciousness
1 other identifier
observational
100
0 countries
N/A
Brief Summary
The aim of this study is to determine whether ALDH2 gene polymorphisms (G/G, G/A A/A) have effect on the potency of propofol.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Feb 2019
Shorter than P25 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 27, 2018
CompletedFirst Posted
Study publicly available on registry
December 3, 2018
CompletedStudy Start
First participant enrolled
February 1, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2019
CompletedDecember 3, 2018
January 1, 2018
5 months
November 27, 2018
November 30, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Effect-site concentration
patient's effect-site concentration when he/she loss consciousness
immediately after patient lose his/her consciousness
Study Arms (2)
G/G group
Patients who are determined to be G/G genotype.
G/A A/A group
Patients who are determined to be G/A or A/A genotypes.
Interventions
Patients will be induced to unconsciousness using propofol intravenously.
Eligibility Criteria
operation rooms for cardiac surgeries in our institution（a major hospital in China)
You may qualify if:
- ASA II
You may not qualify if:
- ASA III-IV
- OSAS
- hepatic and renal insufficiency
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 27, 2018
First Posted
December 3, 2018
Study Start
February 1, 2019
Primary Completion
June 30, 2019
Study Completion
December 31, 2019
Last Updated
December 3, 2018
Record last verified: 2018-01