Detection of Myocardial Dysfunction in Non-severe Subarachnoid Hemorrhage (WFNS 1-2) Using Speckle-tracking Echocardiography (STRAIN)

NCT03761654 | Completed

• 1 other identifier: CHUBX 2018/51
• Study Type: observational
• Target: 117
• Locations: 1 country
• Sites: 1

Brief Summary

Subarachnoid hemorrhage (SAH) can cause transient myocardial dysfunction. Recently, it have been reported that myocardial dysfunctions that occur in SAH are associated with poor outcomes. It therefore appears essential to detect theses dysfunctions with the higher sensitivity as possible. Strain measurement using speckle-tracking echocardiography may detect myocardial dysfunction with great sensitivity. The main objective of this study is to assess the prevalence of myocardial dysfunction in "non-severe" SAH (defined by a WFNS grade 1 or 2), using speckle-tracking echocardiography. This study also aims to analyse Strain measurement with classical echocardiography and serum markers (troponin, BNP) of cardiac dysfunction.

Conditions

Subarachnoid Hemorrhage (SAH); Left Ventricular Dysfunction; Stress Cardiomyopathy

Keywords

Subarachnoid Hemorrhage (SAH); Left Ventricular Dysfunction; Intensive Care Unit; Speckle-tracking; STRAIN

Outcome Measures

Primary Outcomes (1)

• Global Longitudinal Strain

  It is calculated using values of longitudinal strain measured in the three-,four-, and two-chamber of the left ventricle of the heart. GLS is expressed as percentage. Strain is a measure of myocardial muscle fiber shortening during contraction and is calculated as the systolic segment shortening between end-systolic (ES) segment length (L) and end-diastolic (ED) length: strain = (-LES - LED)/LED x 100 %.

  Day 1 of hospitalization

Secondary Outcomes (6)

• Global Longitudinal Strain

  Day 3 of hospitalization

• Global Longitudinal Strain

  Day 7 of hospitalization

• Change of Left Ventricular Ejection Fraction using Simpson technique

  Days 1, 3 and 7 of hospitalization

• Change in serum troponin level

  Days 1, 3 and 7 of hospitalization

• Change in brain natriuretic peptide (BNP) level

  Days 1, 3 and 7 of hospitalization

Study Arms (1)

Patients with a "non-severe" subarachnoid hemorrhage

Diagnostic Test: Global Longitudinal Strain measure

Interventions

Global Longitudinal Strain measure DIAGNOSTIC_TEST

Global Longitudinal Strain measure on day 1 of hospitalization

Patients with a "non-severe" subarachnoid hemorrhage

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patient older than 18 years hospitalized in neuro-intensive care unit with a "non-severe" subarachnoid hemorrhage (WFNS 1 or 2)

You may qualify if:

• patient older than 18 years
• hospitalized in neuro-intensive care unit with a "non-severe" subarachnoid hemorrhage (WFNS 1 or 2)

You may not qualify if:

• low echogenicity
• history of cardiac malformation or cardiac surgery
• severe valvular heart disease
• dilated cardiomyopathy
• acute coronary syndrome
• permanent arrythmia
• patient refusal

Sponsors & Collaborators

• University Hospital, Bordeaux: lead

Study Sites (1)

CHU de Bordeaux

Bordeaux, 33076, France

Location

MeSH Terms

Conditions

Subarachnoid Hemorrhage; Ventricular Dysfunction, Left; Takotsubo Cardiomyopathy; Sprains and Strains

Condition Hierarchy (Ancestors)

Intracranial Hemorrhages; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Ventricular Dysfunction; Heart Diseases; Cardiomyopathies; Wounds and Injuries

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 29, 2018
• First Posted: December 3, 2018
• Study Start: January 2, 2019
• Primary Completion: December 25, 2020
• Study Completion: January 1, 2021
• Last Updated: January 6, 2021

Record last verified: 2021-01

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)