Glucose Homeostasis in Pseudohypoparathyroidism

NCT03761290 | Terminated

• 1 other identifier: Shoemaker R03
• Study Type: observational
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

It is increasingly recognized that Pseudohypoparathyroidism type 1A (PHP1A) is associated with an increased risk of type 2 diabetes but the mechanism is unknown. In this pilot study we will assess β-cell function in patients with PHP1A and pseudopseudohypoparathyroidism PPHP.

Conditions

Pseudohypoparathyroidism and Pseudopseudohypoparathyroidism; Pseudohypoparathyroidism Type Ia; Albright Hereditary Osteodystrophy

Outcome Measures

Primary Outcomes (1)

• Insulin sensitivity (Si)

  baseline

Study Arms (3)

Pseudphypoparathyroidism type 1A (PHP1A)

Case

Pseudopseudohypoparathyroidism (PPHP)

Case

Controls

Matched control group

Eligibility Criteria

• Age: 6 Years - 50 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients with PHP1A/PPHP and matched controls

You may qualify if:

• Diagnosis of PHP1A/PPHP
• Age between 6 and 50 years old
• Controls will be matched based on:
• Gender
• Race
• Age (±2 years if \<25 years old or ±5 years if ≥25 years old)
• BMI (±2 kg/m2)
• Diabetes status

You may not qualify if:

• Treatment with appetite-altering drug or initiation of a new weight loss program in the past 3 months
• Type 1 diabetes
• Type 2 diabetes treated with insulin or GLP-1 receptor agonists or A1c \>9%at their most recent clinic visit
• Pregnant or lactating women

Sponsors & Collaborators

• Vanderbilt University Medical Center: lead

Study Sites (1)

Vanderbilt University Medical Center

Nashville, Tennessee, 37212, United States

Location

Related Publications (1)

• Perez KM, Curley KL, Slaughter JC, Shoemaker AH. Glucose Homeostasis and Energy Balance in Children With Pseudohypoparathyroidism. J Clin Endocrinol Metab. 2018 Nov 1;103(11):4265-4274. doi: 10.1210/jc.2018-01067.

  PMID: 30085125 BACKGROUND

Related Links

• Vanderbilt PHP Research Page

MeSH Terms

Conditions

Pseudohypoparathyroidism; Pseudopseudohypoparathyroidism

Condition Hierarchy (Ancestors)

Bone Diseases, Metabolic; Bone Diseases; Musculoskeletal Diseases; Metal Metabolism, Inborn Errors; Metabolism, Inborn Errors; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Metabolic Diseases; Nutritional and Metabolic Diseases; Calcium Metabolism Disorders

Study Officials

• Ashley H Shoemaker, MD

  Vanderbilt University Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Pediatrics

Study Record Dates

• First Submitted: November 29, 2018
• First Posted: December 3, 2018
• Study Start: June 19, 2019
• Primary Completion: April 30, 2021
• Study Completion: April 30, 2021
• Last Updated: May 4, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)