Molecular and Cellular Characterization of Skull Base Tumors
1 other identifier
observational
4,000
1 country
1
Brief Summary
The purpose of the study is to analyze biological samples and genetic material for basic science research investigating the molecular and cellular characterization of skull base tumors.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Oct 2018
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 3, 2018
CompletedFirst Submitted
Initial submission to the registry
October 31, 2018
CompletedFirst Posted
Study publicly available on registry
November 30, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 3, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
October 3, 2028
September 22, 2025
September 1, 2025
10 years
October 31, 2018
September 19, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Patient overall survival will be measured and reported.
There will be one outcome measure: overall survival.
Through study completion, an average of 10 years
Interventions
Understanding the biology of skull base tumors will teach the investigators about the genesis and/or mechanisms of treatment resistance. The investigators hope to ultimately identify new targets which will add to the armamentarium by which to treat these tumors.
Eligibility Criteria
Patients with a skull base tumor
You may qualify if:
- Diagnosis of a skull base tumor
You may not qualify if:
- Insufficient tumor sample at time of resection
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15213, United States
Biospecimen
Blood and Tissue
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Paul Gardner, MD
Associate Professor
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
October 31, 2018
First Posted
November 30, 2018
Study Start
October 3, 2018
Primary Completion (Estimated)
October 3, 2028
Study Completion (Estimated)
October 3, 2028
Last Updated
September 22, 2025
Record last verified: 2025-09
Data Sharing
- IPD Sharing
- Will not share
If data is to be shared it will be de-identified with proper data use agreements in place.