Angiomatoid Fibrous Histiocytoma: a Single Institution Case-series

NCT03759327 | Completed

• 1 other identifier: AFH
• Study Type: observational
• Target: 9
• Locations: 1 country
• Sites: 1

Brief Summary

single institution cases series review of histological and clinical data

Conditions

Angiomatoid Fibrous Histiocytoma

Outcome Measures

Primary Outcomes (2)

• selection and review of 9 cases of Angiomatoid Fibrous Histiocytoma

  investigators will review all the medical records, radiological imaging, and histological slides of all cases to identify the best therapeutic approach.

  at baseline (Day0)

• analysis of EWS-CREB1 and EWS-ATF1 mutation and ALK expression on tissue tumor material

  In all cases immunohistochemistry will be performed on slides/formalin-fixed paraffin-embedded tissue tumor material. EWS-CREB1 and EWS-ATF1 mutation and ALK expression will be analyzed with RT-PCR and/or FISH analysis.

  at baseline (Day0)

Eligibility Criteria

• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Male and Female with diagnosis of Angiomatoid Fibrous Histiocytoma with histological slides/formalin-fixed paraffin-embedded tissue tumor blocks from archive available to perform the histology analysis

You may qualify if:

• Male and female patients treated at Rizzoli Institute from 01 January 2006 to 31 December 2017
• Diagnosis of Angiomatoid Fibrous Histiocytoma
• Histological slides/formalin-fixed paraffin-embedded tissue tumor (FFPE) blocks from archive available to perform the histology analysis
• Written informed consent prior to any study-specific analysis and/or data collection

You may not qualify if:

• Patients with histological diagnosis different from Angiomatoid Fibrous Histiocytoma

Sponsors & Collaborators

• Istituto Ortopedico Rizzoli: lead

Study Sites (1)

IRCC Rizzoli Orthopedic Institute

Bologna, 40136, Italy

Location

Related Publications (5)

• Antonescu CR, Dal Cin P, Nafa K, Teot LA, Surti U, Fletcher CD, Ladanyi M. EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma. Genes Chromosomes Cancer. 2007 Dec;46(12):1051-60. doi: 10.1002/gcc.20491.

  PMID: 17724745 RESULT

• Bohman SL, Goldblum JR, Rubin BP, Tanas MR, Billings SD. Angiomatoid fibrous histiocytoma: an expansion of the clinical and histological spectrum. Pathology. 2014 Apr;46(3):199-204. doi: 10.1097/PAT.0000000000000073.

  PMID: 24614712 RESULT

• Chen G, Folpe AL, Colby TV, Sittampalam K, Patey M, Chen MG, Chan JK. Angiomatoid fibrous histiocytoma: unusual sites and unusual morphology. Mod Pathol. 2011 Dec;24(12):1560-70. doi: 10.1038/modpathol.2011.126. Epub 2011 Aug 5.

  PMID: 21822206 RESULT

• Noujaim J, Jones RL, Swansbury J, Gonzalez D, Benson C, Judson I, Fisher C, Thway K. The spectrum of EWSR1-rearranged neoplasms at a tertiary sarcoma centre; assessing 772 tumour specimens and the value of current ancillary molecular diagnostic modalities. Br J Cancer. 2017 Feb 28;116(5):669-678. doi: 10.1038/bjc.2017.4. Epub 2017 Jan 31.

  PMID: 28141799 RESULT

• Rossi S, Szuhai K, Ijszenga M, Tanke HJ, Zanatta L, Sciot R, Fletcher CD, Dei Tos AP, Hogendoorn PC. EWSR1-CREB1 and EWSR1-ATF1 fusion genes in angiomatoid fibrous histiocytoma. Clin Cancer Res. 2007 Dec 15;13(24):7322-8. doi: 10.1158/1078-0432.CCR-07-1744.

  PMID: 18094413 RESULT

Biospecimen

Retention: SAMPLES WITHOUT DNA

immunohistochemistry will be performed on FFPE material. EWS-CREB1 and EWS-ATF1 mutation and ALK expression will be analyzed with RT-PCR and/or FISH analysis.

MeSH Terms

Conditions

Histiocytoma, Angiomatoid Fibrous

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 22, 2018
• First Posted: November 30, 2018
• Study Start: November 30, 2018
• Primary Completion: May 1, 2019
• Study Completion: May 25, 2019
• Last Updated: February 13, 2020

Record last verified: 2018-11

Data Sharing

• IPD Sharing: Will not share

Locations

IT (1)