Cranial Electrotherapy Stimulation in the Treatment of Posttraumatic Stress Disorder

NCT03757494 | Completed FDA Device

• 1 other identifier: 1286051
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

This is a research study that will look at how well a treatment called Cranial Electrotherapy Stimulation (CES) works for patients who struggle with symptoms of Posttraumatic Stress Disorder. Cranial Electrotherapy Stimulation is delivered using a device called Alpha-Stim®. This is a safe, non-invasive treatment that applies a low-level pulsed electric current through the brain using clip-on electrodes attached to the earlobes. Cranial Electrotherapy Stimulation treats conditions such as physical pain, anxiety, and depression.

Conditions

PTSD, Post Traumatic Stress Disorder

Outcome Measures

Primary Outcomes (1)

• Feasibility of Alpha-Stim® Cranial Electrotherapy Stimulation (CES) as a treatment for Posttraumatic Stress Disorder (PTSD).

  We will deem the treatment feasible if ≥ 6 participants complete the protocol, based on completion of ≥ 60% treatments (3 out of 5 treatment days, weekly at home), and attending and completing ≥ 75% of the weekly assessments, including the week 1 baseline and week 4 treatment completion visit

  1 year

Secondary Outcomes (1)

• Safety of the Alpha-Stim® Cranial Electrotherapy Stimulation (CES) as a treatment for Posttraumatic Stress Disorder.

  1 year

Other Outcomes (1)

• Efficacy of Alpha-Stim® Cranial Electrotherapy Stimulation (CES) as a treatment for Posttraumatic Stress Disorder.

  1 year

Study Arms (1)

Use of Alpha Stim

EXPERIMENTAL

Use of Alpha Stim Device

Device: Alpha Stim

Interventions

Alpha Stim DEVICE

Use of Alpha Stim Device

Use of Alpha Stim

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• To ensure participants can safely receive Alpha-Stim®, eligible participants must meet all established screening criteria for safety during Alpha-Stim® using a safety screener (as assessed during phone screen and medical records review). We are screening to access for metal. These are conservative measures require a patient not having the following (unless MRI-safe): Cardiac pacemaker, implanted device (deep brain stimulation) or metal in the brain, cervical spinal cord, or upper thoracic spinal cord. The patient would additionally be required to not have an implanted cardiac defibrillator;
• Outpatients 18-70 years of age (inclusive);
• Meet DSM-V criteria for PTSD (acute or chronic) at the time of the screening and/or baseline visit; symptoms.
• Have a baseline score of "Moderately Ill" or worse on the CGI-S;
• Be on a stable psychotropic regimen for at least 6 weeks prior to baseline, or no psychotropic medication at all (for at least 6 weeks prior to baseline), and be willing to maintain the current regimen and dosing for the duration of the study (unless medically necessary to make changes with notification of research staff);
• (7) If female and of child bearing potential, agree to use an acceptable method of birth control for the duration of the study treatment period; (8) Be willing and able to comply with all study related procedures and visits; (9) Be capable of independently reading and understanding patient information materials and giving written informed consent.

You may not qualify if:

• Participants will be excluded from participation if they meet any of the following:
• Are pregnant or lactating or planning to become pregnant within the next three months;
• Have a lifetime history of loss of consciousness due to head injury for greater than 10 minutes, or any lifetime history of loss of consciousness due to a head injury with documented evidence of brain injury (including brain atrophy);
• Current (or past if appropriate) significant neurological disorder, or lifetime history of a) seizure disorder b) primary or secondary CNS tumors c) stroke or d) cerebral aneurysm;
• Unstable medical illness, or, in the opinion of the investigator, significant absence of appropriate medical care;
• Current Axis 1 primary psychotic disorder, or bipolar I disorder, active moderate/severe substance use disorders (within the last month as assessed by review of the medical records and veteran self-report, excluding nicotine/caffeine). Veterans on stable (\>3 months), monitored opiate agonist therapy may be included at the investigator's discretion;
• Past failed treatment with rTMS or ECT; any past treatment with deep brain stimulation or vagus nerve stimulation;
• Have active suicidal intent or plan as detected on screening assessments, or in the Investigator's opinion, is likely to attempt suicide within the next six months;
• Mental retardation or cognitive impairment
• History of stroke, Parkinson's Disease, Multiple Sclerosis, or seizures
• Current use of Transcutaneous electrical nerve stimulation (TENS) unit
• Previous history of Alpha-Stim® use
• Inability to read and write in English
• Incapacity to make informed medical decisions for any reason
• Pregnancy: Pregnant women are not eligible for the study. Women with potential for pregnancy will receive a pregnancy test provided by the VA prior to the study. Women of childbearing capacity are eligible for the study. Contraceptive plans will be discussed and if they are determined to be inadequate, the participant will be excluded from the study.

Sponsors & Collaborators

• White River Junction Veterans Affairs Medical Center: lead

Study Sites (1)

White River Junction VAMC

White River Junction, Vermont, 05009, United States

Location

MeSH Terms

Conditions

Combat Disorders

Condition Hierarchy (Ancestors)

Stress Disorders, Traumatic; Trauma and Stressor Related Disorders; Mental Disorders

Study Officials

• James K Rustad, MD

  White River Junction Veterans Affairs Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DEVICE FEASIBILITY
• Intervention Model: SINGLE GROUP
• Sponsor Type: FED
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Using Alpha Stim

Study Record Dates

• First Submitted: October 17, 2018
• First Posted: November 29, 2018
• Study Start: October 18, 2018
• Primary Completion: September 21, 2022
• Study Completion: September 21, 2022
• Last Updated: January 31, 2023

Record last verified: 2023-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)