NCT03755726

Brief Summary

This registry aims to provide the first prospective, multicentric database of patients with malignant hypertension. It will allow to assess modern epidemiology of the disease, diversity of current management and care pathway, to deepen our pathophysiological knowledges, to modernize the definition of this form of hypertension and its diagnostic criteria. The network that will emerge will finally lead to the opportunity of setting up therapeutic trials and establishing recommendations based on solid scientific evidence.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,200

participants targeted

Target at P75+ for all trials

Timeline
102mo left

Started Sep 2019

Longer than P75 for all trials

Geographic Reach
2 countries

37 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress44%
Sep 2019Sep 2034

First Submitted

Initial submission to the registry

November 26, 2018

Completed
2 days until next milestone

First Posted

Study publicly available on registry

November 28, 2018

Completed
10 months until next milestone

Study Start

First participant enrolled

September 20, 2019

Completed
15 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 20, 2034

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 20, 2034

Last Updated

March 23, 2026

Status Verified

March 1, 2026

Enrollment Period

15 years

First QC Date

November 26, 2018

Last Update Submit

March 19, 2026

Conditions

Malignant Hypertension

Outcome Measures

Primary Outcomes (1)

  • prognosis

    5-year prognosis for patients with malignant hypertension

    5 years

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients with malignant hypertension

You may qualify if:

  • Malignant hypertension according to the classic definition (Severe hypertension, above 180/110 associated with severe hypertensive retinopathy)
  • Severe hypertension (above 180/110) associated with acute damage of 3 target organ due to high blood pressure

You may not qualify if:

  • Age \< 18 years old
  • Patients who cannot freely give their consent, or patients who refuse to participate
  • Dialysis

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (37)

CH d'Annecy

Annecy, France

RECRUITING

CH de la côte Basque

Bayonne, 64109, France

RECRUITING

Avicenne APHP

Bobigny, 93009, France

RECRUITING

CHU - Hôpital St André

Bordeaux, 33000, France

RECRUITING

CH de Chalon sur Saone

Chalon-sur-Saône, France

RECRUITING

CH Métropole

Chambéry, 73011, France

RECRUITING

CHU de Clermont FERRAND

Clermont-Ferrand, France

RECRUITING

Hôpital Henri Mondor

Créteil, France

RECRUITING

CH de Dinard

Dinard, 35800, France

RECRUITING

CHU Michallon

Grenoble, 38043, France

RECRUITING

hôpital de Haguenau

Haguenau, 67504, France

RECRUITING

Pôle Santé Sud

Le Mans, France

RECRUITING

CH de Libourne

Libourne, 33505, France

RECRUITING

CHRU de Lille

Lille, 59037, France

RECRUITING

Clinique Vert Coteau

Marseille, 13012, France

RECRUITING

Hopital de la conception

Marseille, 13385, France

RECRUITING

CH Martigues

Martigues, 13500, France

RECRUITING

CHU de Montellier

Montpellier, France

RECRUITING

CHU - Hôpital Laennec

Nantes, 44800, France

RECRUITING

Hôpital Saint Joseph

Paris, 75014, France

RECRUITING

Hôpital Européen Georges Pompidou

Paris, 75015, France

RECRUITING

APHP Bichat

Paris, 75877, France

RECRUITING

Fondation Adolphe de Rothschild

Paris, France

RECRUITING

Hôpital Tenon

Paris, France

RECRUITING

CH de PAU

Pau, 64000, France

RECRUITING

CHU de Pointe à Pitre

Pitres, 97159, France

NOT YET RECRUITING

CHU de Poitiers

Poitiers, 86021, France

RECRUITING

CHU de Rennes

Rennes, 35033, France

RECRUITING

CHU de ROUEN

Rouen, 76000, France

RECRUITING

Clinique sainte Clotilde

Saint-Denis, 97400, France

RECRUITING

CHU de St Etienne

Saint-Etienne, 42055, France

RECRUITING

CH de St Nazaire

Saint-Nazaire, 44606, France

RECRUITING

CHU de Strasbourg

Strasbourg, 67000, France

RECRUITING

CHU de Toulouse Rangueil

Toulouse, 31059, France

RECRUITING

CHU de Tours

Tours, 37044, France

RECRUITING

CH de Valenciennes

Valenciennes, France

RECRUITING

National Institute of Cardiology

Warsaw, Poland

NOT YET RECRUITING

Related Publications (1)

  • Boulestreau R, Lorthioir A, Dreau H, Persu A, Cremer A, Tharaux PL, Rubin S, Maier B, Mazighi M, Seris A, Paques M, Bonnin S, Halimi JM, Debeugny S, Gosse P; for the HAMA investigators. Baseline characteristics of the first 302 patients included for acute malignant hypertension crisis in the prospective multidisciplinary HAMA cohort. J Hypertens. 2024 Dec 1;42(12):2131-2138. doi: 10.1097/HJH.0000000000003851. Epub 2024 Oct 7.

    PMID: 39351849DERIVED

MeSH Terms

Conditions

Hypertension, Malignant

Condition Hierarchy (Ancestors)

HypertensionVascular DiseasesCardiovascular Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

November 26, 2018

First Posted

November 28, 2018

Study Start

September 20, 2019

Primary Completion (Estimated)

September 20, 2034

Study Completion (Estimated)

September 20, 2034

Last Updated

March 23, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will not share

Locations

FR(36)PL(1)