C.A.P.A.B.L.E. (CrossFit® and Physical Activity: A Better Life Experience)

NCT03750981 | Recruiting

• 1 other identifier: 2018-091
• Study Type: interventional
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

This study will introduce cancer survivors to cross-training with the expectation that the program proposed will ultimately result in superior improvements in functional performance, body composition and quality of life compared with the current American Cancer Society (ACS) guidelines for cancer survivors.

Conditions

Cancer Survivors

Outcome Measures

Primary Outcomes (15)

• Enrollment rates

  Enrollment rates will be calculated among those who respond to notices about the study and adherence to the program among those who enroll and to describe reported barriers to participation among respondents who do not ultimately enroll

  Baseline

• Change in functional performance and variability in functional performance among adult cancer survivors enrolled in a high-intensity functional training program

  Physical measures of strength will be assessed by a certified trainer. To assess strength improvements deadlifts (lifting weights from floor to waist) will be performed in 10 lb. increments. A circuit will also be done with strength measures including sit ups and push ups.

  Baseline to 12 weeks

• Change in functional performance and variability in functional performance among adult cancer survivors enrolled in a high-intensity functional training program

  Physical measures of flexibility will be assessed by a certified trainer. To assess flexibility sit ups, squats and push up level (floor, knees, on an elevated bar, etc) will be recorded.

  Baseline to 12 weeks

• Change in functional performance and variability in functional performance among adult cancer survivors enrolled in a high-intensity functional training program

  Physical measures of cardiovascular strength will be assessed by a certified trainer. To assess cardiovascular strength maximum effort on a stationary bike will be recorded. Additionally, in the circuit, a maximum effort on a rowing machine will be recorded.

  Baseline to 12 weeks

• Change in self-reported health-related quality of life (HRQOL) and variability using the FACT questionnaire

  Quality of Life will be measured using the Functional Assessment of Cancer Therapy: General (FACT), developed by Dr. David Cella. The FACT-G is 27 items assessing physical, social/ family, emotional and functional well-being. The survey uses a five-point scale from 0 (not at all) to 4 (very much). Scoring the FACT-G is performed through a sum of item scores. Higher scores indicate a better health state.

  Baseline to 12 weeks

• Change in Body Composition

  Changes in weight in kg

  Baseline to 12 weeks

• Change in Body Composition

  Changes in body fat percentage

  Baseline to 12 weeks

• Change in Body Composition

  Changes in visceral fat percentage

  Baseline to 12 weeks

• Change in Body Composition

  Changes in muscle mass percentage

  Baseline to 12 weeks

• Change in Body Composition

  Changes in body mass index (BMI) - Weight and height will be combined to report BMI in kg/ m2

  Baseline to 12 weeks

• Change in Body Composition

  Changes in resting metabolism value

  Baseline to 12 weeks

• Change in Motivation

  Motivation to exercise will be collected via a survey

  Baseline to 12 weeks

• Satisfaction with the Program

  Satisfaction with the program will be collected via a survey

  12 weeks

• Program Adherence

  Program adherence will be calculated based on how many sessions each participant attended in the 13 week program, 36 session design.

  12 weeks

• Height

  Height will be collected in meters to use in the calculation of Body Mass Index

  Baseline

Study Arms (1)

A 12-week pilot intervention study introducing a high-intensi

OTHER

Behavioral: 12 week pilot intervention study.

Interventions

12 week pilot intervention study. BEHAVIORAL

Participants will begin a 12-week high-intensity functional training program conducted at CrossFit® in the D, located in downtown Detroit, Northville Athletix in Northville and Five Lakes CrossFit® in Farmington Hills.

A 12-week pilot intervention study introducing a high-intensi

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged 18 years or older at time of program recruitment
• Diagnosed with any cancer
• Cleared from their physician to participate in the program (We assume that most patients will have completed treatment, however if a patient is currently under treatment, this should be their oncologist. If the patient is not currently undergoing treatment, this could be primary care physician or oncologist).
• Available transportation to and from the facility on session days

You may not qualify if:

• Widely metastatic cancers to the brain or bone may be excluded.

Sponsors & Collaborators

• Barbara Ann Karmanos Cancer Institute: lead

Study Sites (1)

Barbara Ann Karmanos Cancer Institute

Detroit, Michigan, 48201, United States

RECRUITING

Study Officials

• Jennifer Beebe-Dimmer, MPH, PhD.

  Barbara Ann Karmanos Cancer Institute

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jennifer B Beebe-Dimmer, MPH, PhD.

CONTACT

(313) 578-4209; dimmerj@karmanos.org

Tara Baird, M.Ed.

CONTACT

(313) 578-4246; bairdt@karmanos.org

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 15, 2018
• First Posted: November 23, 2018
• Study Start: November 12, 2018
• Primary Completion (Estimated): November 30, 2027
• Study Completion (Estimated): November 30, 2028
• Last Updated: November 6, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)