BPF Genetics of ILD Study

NCT03747627 | Active Not Recruiting DMC

• 1 other identifier: MS001
• Study Type: observational
• Target: 475
• Locations: 1 country
• Sites: 2

Brief Summary

The investigators aim to examine the genetic determinants of interstitial lung disease in a cohort of subjects with regular exposure to pigeons, a known cause of one form of interstitial lung disease known as hypersensitivity pneumonitis. In addition we will examine immunological causes for hypersensitivity pneumonitis in this group. We anticipate our work will provide insights of use to clinicians and patients with hypersensitivity pneumonitis and other interstitial lung diseases.

Conditions

Lung; Disease, Interstitial, With Fibrosis; Alveolitis, Extrinsic Allergic; Bird Fancier's Lung; Idiopathic Interstitial Pneumonias; Lung Diseases, Interstitial; Idiopathic Pulmonary Fibrosis

Keywords

Interstitial Lung Disease (ILD); Hypersensitivity Pneumonitis; Idiopathic Pulmonary Fibrosis (IPF); Extrinsic Allergic Alveolitis (EAA); Bird Fancier's Lung; Genetics

Outcome Measures

Primary Outcomes (1)

• Relationship of specific genetic markers to development of interstitial lung disease

  Participants will be screened for MUC5B genetic profile to allow examination of MUC5B genetic profile relationship with risk of developing interstitial lung disease in this group

  5 years

Interventions

Genetic profiling DIAGNOSTIC_TEST

All participating subjects will undergo detailed genetic analysis, with the aim of detecting novel genetic drivers for the development of interstitial lung disease in the context of known sensitising agent (pigeon antigen)

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants in the sport of Pigeon racing

You may qualify if:

• regular exposure to racing pigeons

You may not qualify if:

• Unwilling to participate

Sponsors & Collaborators

• University of Dundee: lead
• University of Leicester: collaborator
• University of Glasgow: collaborator
• Newcastle University: collaborator
• British Lung Foundation: collaborator
• British Pigeon Fanciers Medical Research: collaborator

Study Sites (2)

Scottish Homing Union

Lanark, Lanark, ML11 9AX, United Kingdom

Location

Royal Pigeon Racing Association Meeting

Blackpool, FY1 1HL, United Kingdom

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood samples will be prepared for DNA analysis

MeSH Terms

Conditions

Disease; Alveolitis, Extrinsic Allergic; Bird Fancier's Lung; Idiopathic Interstitial Pneumonias; Lung Diseases, Interstitial; Idiopathic Pulmonary Fibrosis

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Lung Diseases; Respiratory Tract Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases; Occupational Diseases; Pulmonary Fibrosis

Study Officials

• Mark Spears, PhD, FRCP

  NHS Tayside & University of Dundee

  PRINCIPAL INVESTIGATOR

• Louise Wain, PhD

  University of Leicester

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 5 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr Mark Spears, Consultant in Respiratory Medicine

Study Record Dates

• First Submitted: November 14, 2018
• First Posted: November 20, 2018
• Study Start: January 19, 2019
• Primary Completion: January 19, 2025
• Study Completion (Estimated): January 1, 2028
• Last Updated: April 25, 2025

Record last verified: 2025-04

Locations

GB (2)