NCT03745027

Brief Summary

This cross-sectional study was conducted at the Reproductive Endocrinology and Invitro Fertilization (REI) unit of our hospital, following the approval of the hospital's ethics committee. Patients who underwent gonadotropin-releasing hormone agonist (GnRHa) treatment were enrolled in the study. During oocyte retrieval, follicular fluids of mature follicles (≥18 mm) were collected and pooled for each patient. The thiobarbituric acid method was used for the sialic acid levels and the absorbance values were measured by a spectrophotometer at 549 nm.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
87

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jan 2014

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2014

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2016

Completed
2.9 years until next milestone

First Submitted

Initial submission to the registry

November 10, 2018

Completed
9 days until next milestone

First Posted

Study publicly available on registry

November 19, 2018

Completed
Last Updated

February 26, 2019

Status Verified

November 1, 2018

Enrollment Period

2 years

First QC Date

November 10, 2018

Last Update Submit

February 24, 2019

Conditions

in Vitro Fertilization

Keywords

in vitro fertilizationsialic acid

Outcome Measures

Primary Outcomes (1)

  • Number of patients who become pregnant

    Number of patients who become pregnant will be recorded

    during procedure

Study Arms (1)

In vitro fertilization

EXPERIMENTAL

Paients undergoing in vitro fertilization with Gonadotropin-releasing Hormone agonist. Follicular fluid sialic acid levels will be measured.

Diagnostic Test: in vitro fertilization

Interventions

in vitro fertilizationDIAGNOSTIC_TEST

All patients underwent gonadotropin-releasing hormone agonist (GnRHa) treatment for in vitro fertilization and Follicular fluid sialic acid levels are measured.

In vitro fertilization

Eligibility Criteria

Age18 Years - 40 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • under 40 years of age,
  • normal thyroid and prolactin hormone levels,
  • a basal follicle stimulating hormone (FSH) level \<10 mIU/mL,
  • body mass index (BMI) of 19-30 kg/m2

You may not qualify if:

  • a history of ovarian surgery, endometriosis, uterine anomaly,
  • any endocrine disease including congenital adrenal hyperplasia,
  • smokers,
  • use of any medications and hormones in the last 3 months.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Kanuni SSRTH

Istanbul, 34303, Turkey (Türkiye)

Location

Study Officials

  • Berna Aslan A Çetin

    KSSTRH

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
DIAGNOSTIC
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Md, ObGYN, Principal Investigator

Study Record Dates

First Submitted

November 10, 2018

First Posted

November 19, 2018

Study Start

January 1, 2014

Primary Completion

January 1, 2016

Study Completion

January 1, 2016

Last Updated

February 26, 2019

Record last verified: 2018-11

Locations

TU(1)