Association Between Pseudoexfoliation Syndrome and Diabetes Mellitus

NCT03741153 | Unknown

• 1 other identifier: PXSDM
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

Pseudoexfoliation syndrome (PEX) is characterized by the deposition of a distinctive fibrillar material in the anterior segment of the eye and was first described in 1917 by Lindberg. It is frequently associated with open angle glaucoma, known as pseudoexfoliation glaucoma, which is one of the most common identifiable forms of secondary open angle glaucoma worldwide. Despite extensive research, the exactchemical nature of the fibrillar material is unknown. It is believed to be secreted multifocally in the iris pigment epithelium, the ciliary epithelium, and the peripheral anterior lens epithelium.

Conditions

Lens Diseases

Outcome Measures

Primary Outcomes (1)

• the percentage of diabetic patients with pseudo-exfoliation syndrome

  slit lamp examination of all diabetic patients to get the percentage of those with pseudo-exfoliation syndrome

  10 minutes

Study Arms (2)

study group

includes patients who will be diagnosed with Pseudoexfoliation syndrome

Device: slit lamp

control group

age matched controls who do not have Pseudoexfoliation syndrome

Device: slit lamp

Interventions

slit lamp DEVICE

1. Presence of white grayish exfoliation material on the anterior lens capsule and / or the pupillary margin. 2. Poor pupillary dilatation due to atrophy of the dilator pupillae muscle. 3. The presence of pseudoexfoliative material (PXF)in cilliary processes and zonules. 4. presence of PXF material scattered on corneal endothelium. 5. Flecks of the exfoliative material on the anterior chamber which leads to glaucoma.

control group; study group

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients who will be diagnosed with pseudo-exfolian syndrome

You may qualify if:

• Phakic patients presenting to Ophthalmology outpatient clinic Of Assiut University Hospital.

You may not qualify if:

• Patients with previous intraocular surgery.

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Lens Diseases

Interventions

Slit Lamp

Condition Hierarchy (Ancestors)

Eye Diseases

Intervention Hierarchy (Ancestors)

Ophthalmoscopes; Diagnostic Equipment; Equipment and Supplies

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: November 11, 2018
• First Posted: November 14, 2018
• Study Start: January 1, 2019
• Primary Completion: December 1, 2020
• Study Completion: March 14, 2021
• Last Updated: November 14, 2018

Record last verified: 2018-11