NCT03740828

Brief Summary

The aim of this study is to demonstrate that the KIDScore D3 may be used to identify those embryos on Day 3 that are most likely to form blastocysts.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
81

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Sep 2016

Geographic Reach
1 country

6 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 20, 2016

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 12, 2017

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 12, 2017

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

November 5, 2018

Completed
9 days until next milestone

First Posted

Study publicly available on registry

November 14, 2018

Completed
Last Updated

November 14, 2018

Status Verified

November 1, 2018

Enrollment Period

1.1 years

First QC Date

November 5, 2018

Last Update Submit

November 12, 2018

Conditions

Keywords

In vitro fertilizationTime-lapseAssisted Reproduction

Outcome Measures

Primary Outcomes (1)

  • Prediction of blastocyst outcome

    The primary endpoint of this study was to assess the association between the adjunct prediction using KIDScore D3 of blastocyst outcome and the actual blastocyst outcome. The Odds Ratio (OR) for the adjunct prediction of blastulation is required to be statistically significantly greater than 1, for good/fair embryos. This will demonstrate that adjunctive use of KIDScore D3 leads to embryologist predictions for Day 5 blastulation that is informative for blastocysts outcome.

    1-2 months

Secondary Outcomes (3)

  • Embryo-Level Diagnostic Performance Measures

    1-2 Months

  • Top 2 Embryo Analysis

    1-2 Months

  • Treatment Level Analyses

    1-2 Months

Study Arms (1)

Women undergoing IVF treatment

Device: KIDScore D3 study

Device: KIDScore D3

Interventions

Embryos are scored using the KIDScore D3 algorithm based on annotated morphokinetic parameters.

Women undergoing IVF treatment

Eligibility Criteria

Sexfemale(Gender-based eligibility)
Gender Eligibility DetailsWomen undergoing IVF treatment
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

European women undergoing IVF treatment and imaging of their embryos with the EmbryoScope system

You may qualify if:

  • Women undergoing IVF treatment

You may not qualify if:

  • Less than 5 actively dividing embryos

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (6)

Fertility Specialists Medical Group, Inc

San Diego, California, 92123, United States

Location

Laurel Fertility Care

San Francisco, California, 94109, United States

Location

Pacific Fertility

San Francisco, California, 94133, United States

Location

South Florida Institute Fro Reproductive Medicine

Miami, Florida, 33143, United States

Location

Midwest Fertility Institute

Carmel, Indiana, 46032, United States

Location

New York Fertility Institute

New York, New York, 10028, United States

Location

Related Publications (1)

  • Petersen BM, Boel M, Montag M, Gardner DK. Development of a generally applicable morphokinetic algorithm capable of predicting the implantation potential of embryos transferred on Day 3. Hum Reprod. 2016 Oct;31(10):2231-44. doi: 10.1093/humrep/dew188. Epub 2016 Sep 8.

MeSH Terms

Conditions

Infertility

Condition Hierarchy (Ancestors)

Genital DiseasesUrogenital Diseases

Study Officials

  • Belinda Dueholm, MSc

    Vitrolife A/S

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
8 Weeks
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 5, 2018

First Posted

November 14, 2018

Study Start

September 20, 2016

Primary Completion

October 12, 2017

Study Completion

October 12, 2017

Last Updated

November 14, 2018

Record last verified: 2018-11

Data Sharing

IPD Sharing
Will not share

Patient data are confidential

Locations