NCT03737942|Unknown
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Sponsor study identifier
observational
60
1 country
1
Study Start
November 15, 2018
Actual (reported)Primary Completion
January 15, 2019
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
March 2019
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
International Diabetes Federation estimates that there are now 415 million adults aged 20-79 with diabetes mellitus worldwide. By 2040 this will rise to 640 million. Although diabetes mellitus is highly prevalent in our environment and one of the most important challenges of modern medicine, only a handful of studies have examined the neuromuscular function in diabetic patients. The shortage of publications in this area is still more surprising if we consider that the neuromuscular blockers are one of the pillars in the administration of general anesthesia. Neuromuscular blockers during surgery are used in tracheal intubation and to improve surgical conditions.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 2019
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 4, 2018
Actual (reported)November 13, 2018
Actual (reported)November 15, 2018
Actual (reported)January 15, 2019
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
March 2019
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
neuromuscular monitoring
Tetanic stimulus , 50 Hz during 5 seconds (tetanic preconditioning).
before operation,till one hour
Motor nerve conduction studies: Were done on right ulner, right median, right common peroneal, and right anterior tibial nerves F-wave (for Median, Ulnar and common peroneal nerves) H-reflex study
Motor nerve conduction studies: Were done on right ulner, right median, right common peroneal, and right anterior tibial nerves F-wave (for Median, Ulnar and common peroneal nerves) H-reflex study
Motor nerve conduction studies: Were done on right ulner, right median, right common peroneal, and right anterior tibial nerves F-wave (for Median, Ulnar and common peroneal nerves) H-reflex study
started by percutaneous stimulation of the cubital nerve at the wrist level
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* patients with diabetes Mellitus type 2. * Patients with suspected difficult airway (Mallampati class III and IV, thyromental distance \<6.5 cm, oral aperture \<3.5 cm) were also excluded. * In relation to kidney function, patients with serum creatinine ≥1.5 mg/dl or more were excluded. * we excluded individuals with GPT or GOT enzyme values ≥42 IU/l or a body mass index (BMI) of \<18.5 kg/m2 or \> 30 kg/m2.
Assiut governorate
Asyut, Egypt
Hafeez KR, Tuteja A, Singh M, Wong DT, Nagappa M, Chung F, Wong J. Postoperative complications with neuromuscular blocking drugs and/or reversal agents in obstructive sleep apnea patients: a systematic review. BMC Anesthesiol. 2018 Jul 19;18(1):91. doi: 10.1186/s12871-018-0549-x.
Nandi R, Basu SR, Sarkar S, Garg R. A comparison of haemodynamic responses between clinical assessment-guided tracheal intubation and neuromuscular block monitoring-guided tracheal intubation: A prospective, randomised study. Indian J Anaesth. 2017 Nov;61(11):910-915. doi: 10.4103/ija.IJA_93_17.
Ghada Abo Elfadl, M.D
Assiut University
First Submitted
November 4, 2018
First Posted
November 13, 2018
Study Start
November 15, 2018
Actual (reported)Primary Completion
January 15, 2019
Estimated (date passed)Serum Resistin Level Following Non-surgical Periodontal Therapy in Diabetic Patients With Chronic Periodontitis
Contact the study team to confirm eligibility.
Kashiwai A, Suzuki T, Ogawa S. Sensitivity to rocuronium-induced neuromuscular block and reversibility with sugammadex in a patient with myotonic dystrophy. Case Rep Anesthesiol. 2012;2012:107952. doi: 10.1155/2012/107952. Epub 2012 Apr 9.
Huang L, Chen D, Li S. Streptozotocin diabetes attenuates the effects of nondepolarizing neuromuscular relaxants on rat muscles. Korean J Physiol Pharmacol. 2014 Dec;18(6):461-7. doi: 10.4196/kjpp.2014.18.6.461. Epub 2014 Dec 30.
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
March 2019
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
November 20, 2018
Record last verified: 2018-11
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