Multi-joint Muscle Fatigability and Gait Performance in People With Multiple Sclerosis
MS_Gait
Assessing the Impact of Muscle Strength and Fatigability on Gait Performance Using Single Joint and Multi-joint Assessments in People With Multiple Sclerosis
1 other identifier
observational
35
1 country
1
Brief Summary
The purpose of this study is to compare walking to leg strength and endurance in people with multiple sclerosis (PwMS). Using these findings, we hope to be better understand what causes PwMS to have problems walking.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Nov 2018
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 3, 2018
CompletedFirst Posted
Study publicly available on registry
November 8, 2018
CompletedStudy Start
First participant enrolled
November 15, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2021
CompletedNovember 8, 2018
November 1, 2018
1.9 years
October 3, 2018
November 7, 2018
Conditions
Outcome Measures
Primary Outcomes (3)
Functional Ambulation Performance (FAP)
The FAP is used to quantify self-selected gait.
1 Day
Hip, knee, and ankle fatigability
For isometric tests, a exhaustion time will be calculated by determining the time that peak impulse declines to 50% using a method validated for individual with MS.
1 Day
Hip, knee, and ankle maximal volitional contraction
Maximal volitional contraction will be measured by the load cell using isometric expressed as peak torque.
1 Day
Secondary Outcomes (2)
Adult Myopathy Assessment Tool (AMAT)
1 Day
5 times sit to stand test (5STS)
1 Day
Other Outcomes (10)
Modified Fatigue Impact Scale (MFIS)
1 Day
Fatigue Severity Score (FSS)
1 Day
Neurology Quality of Life Adult Fatigue Bank (AFB)
1 Day
- +7 more other outcomes
Eligibility Criteria
Patients who receive care at the Washington DC Veteran's Affairs Medical Center Neurology Service and Multiple Sclerosis Center of Excellence - East
You may qualify if:
- Age 18-85 years
- History of multiple sclerosis
- Expanded Disability Status Scale \< 7.0
- Receives care at the Washington DC Veteran's Affairs Medical Center Neurology Service and Multiple Sclerosis Center of Excellence - East
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Washington DC VA Medical Center
Washington D.C., District of Columbia, 20422, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Michael Harris-Love, DSc
Washington DC VA Medical Center
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- FED
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Director, 3MAP Lab, and Assoc. Director, CRC Human Performance Research Unit
Study Record Dates
First Submitted
October 3, 2018
First Posted
November 8, 2018
Study Start
November 15, 2018
Primary Completion
October 1, 2020
Study Completion
October 1, 2021
Last Updated
November 8, 2018
Record last verified: 2018-11