NCT03733795|Unknown
Cerebral Perfusion and Acute Respiratory Failure
Cerebral Perfusion During Intervention for Acute Respiratory Failure
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Cerebral Perfusion During Intervention for Acute Respiratory Failure
Sponsor study identifier
observational
20
1 country
1
Study Start
November 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
October 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
October 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
The most common reason for admitting babies and infants to an intensive care unit is due to respiratory distress (breathing difficulties). At present there are a number of different treatments for respiratory distress. These include drug treatments; non-invasive ventilation, where oxygen is given at high pressure to push it through the baby's lungs: ventilation where the baby is put on a breathing machine; or Extracorporeal Membrane Oxygenation (ECMO). This works by taking the blood from the body via a tube (usually) in the baby's neck, redirecting through a machine that oxygenates the blood, then returning it to the baby through another tube. Currently we know little about how different treatments have a different impact on brain perfusion (how much oxygen the brain gets). Using specialist, noninvasive ultrasound and doppler techniques, we are proposing to monitor the effect of these treatments on the brain.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
November 6, 2018
Actual (reported)November 7, 2018
Actual (reported)October 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
October 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Differences in cerebral blood flow
Transcranial Doppler will be used to measure blood flow in the middle cerebral artery.
5 minutes for each scan
'Healthy babies' to establish 'normal' blood flow in neonates.
Children undergoing extracorporeal membrane oxygenation for acute respiratory failure.
Neonates undergoing conventional treatment for acute respiratory failure.
Transcranial Doppler will be used to measure brain blood flow in the middle cerebral artery.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
An estimation of 20, infants and children admitted with acute respiratory failure will be recruited from Alder Hey.
Alder Hey Children's NHS Foundation Trust
Liverpool, Merseyside, L14 5AB, United Kingdom
First Submitted
November 6, 2018
First Posted
November 7, 2018
Study Start
November 2018
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
October 2020
Estimated (date passed)Contact the study team to confirm eligibility.
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
October 2020
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
November 9, 2018
Record last verified: 2018-10
All information taken will be anonymised.
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Source: ClinicalTrials.gov.
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