Sarcopenia and Orthostatic Hypotension

NCT03732716 | Unknown

• 1 other identifier: 2052
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Elderly patients generally have a tendency for having sarcopenia which refers to muscle loss that may be related to many factors. These patients also have a tendency to falls and injuries. Whether elderly sarcopenic patients have abrupt blood pressure drops upon standing remains unknown. Therefore, in this study, we sought to determine the incidence of orthostatic hypotension in sarcopenic elderly patients and compare it with elderly patients with no sarcopenia.

Conditions

Orthostatic Hypotension; Sarcopenia

Keywords

blood pressure; elderly; sarcopenia; fall

Outcome Measures

Primary Outcomes (1)

• Change in blood pressure

  All blood pressure measurements will be performed in the morning after an eight-hour fasting. After 5-minute rest, the first blood pressure measurement will be taken when the patients are supine. Later, three more consecutive measurements will be recorded when the patients stand up each being one-minute apart. All measurements will be performed using a fully automated sphygmomanometer that is attached with the correctly sized cuff matching to the patients' upper arm circumference. OH is defined as a decrease in systolic blood pressure of 20 mm Hg or a decrease in diastolic blood pressure of 10 mm Hg within 3 minutes of standing. The accompanying symptoms such as dizziness, unable to maintain balance, blurred vision will also be recorded.

  0-3 minutes

Study Arms (2)

Elderly with sarcopenia

50 patients aged 75 or older with sarcopenia Intervention: Each patient's supine and standing blood pressures will be measured.

Diagnostic Test: blood pressure measurement

Elderly without sarcopenia

50 patients aged 75 or older without sarcopenia Intervention: Each patient's supine and standing blood pressures will be measured.

Diagnostic Test: blood pressure measurement

Interventions

blood pressure measurement DIAGNOSTIC_TEST

Intervention: Each patient's supine and standing blood pressure measurements will be recorded

Elderly with sarcopenia; Elderly without sarcopenia

Eligibility Criteria

• Age: 75 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Elderly patients ( 75 or older) with and without sarcopenia

You may qualify if:

• Patients 75 years or older

You may not qualify if:

• Pace-maker
• End stage renal insufficiency
• End stage malignancy
• Dehydration
• Severe anemia ( Hgb \< 8 gr/dl)
• Acute infection
• Marked edema
• Neurodegenerative disease

Sponsors & Collaborators

• Sisli Hamidiye Etfal Training and Research Hospital: lead

Study Sites (1)

Şişli Hamidiye Etfal Education and Research Hospital

Istanbul, 34200, Turkey (Türkiye)

RECRUITING

Related Publications (1)

• Hashimoto Y, Kaji A, Sakai R, Hamaguchi M, Okada H, Ushigome E, Asano M, Yamazaki M, Fukui M. Sarcopenia is associated with blood pressure variability in older patients with type 2 diabetes: A cross-sectional study of the KAMOGAWA-DM cohort study. Geriatr Gerontol Int. 2018 Sep;18(9):1345-1349. doi: 10.1111/ggi.13487. Epub 2018 Jul 24.

  PMID: 30039599 BACKGROUND

MeSH Terms

Conditions

Hypotension, Orthostatic; Sarcopenia

Interventions

Blood Pressure Determination

Condition Hierarchy (Ancestors)

Orthostatic Intolerance; Primary Dysautonomias; Autonomic Nervous System Diseases; Nervous System Diseases; Hypotension; Vascular Diseases; Cardiovascular Diseases; Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Cardiovascular; Diagnostic Techniques and Procedures; Diagnosis; Physical Examination

Study Officials

• Kadriye Orta Kılıçkesmez, Prof

  Şişli Hamidiye Etfal Education and Research Hospital

  STUDY DIRECTOR

Central Study Contacts

Kudret Keskin, MD

CONTACT

0212 3735000; keskinkudret@yahoo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle Investigator

Study Record Dates

• First Submitted: September 6, 2018
• First Posted: November 7, 2018
• Study Start: September 10, 2018
• Primary Completion: December 1, 2018
• Study Completion: December 1, 2018
• Last Updated: November 7, 2018

Record last verified: 2018-11

Locations

TU (1)