Identification of Allergen-reactive Antibodies in the Blood of Pollen Allergic Patients

NCT03727399 | Enrolling By Invitation

• 1 other identifier: 2018-01110
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

The project examines the hypothesis that monoclonal allergen-neutralizing antibodies can be recombinantly produced from B lymphocytes isolated from pollen allergic patients. Patient samples suitable for antibody cloning are selected based on seroprofiling for the respective allergens. The study aims at isolating lymphocytes from patients with potential allergen-neutralizing IgG in serum and to clone antibodies from antibody gene sequences obtained from B cells of those patients.

Conditions

Pollen Allergy

Outcome Measures

Primary Outcomes (1)

• Antibody profiling

  Analysis and IgG profiling of specific antibodies binding major grass- and tree-pollen allergens in allergic patients.

  October 2018 - September 2021

Interventions

blood withdrawal OTHER

Blood withdrawal

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The project population will include adult (\> 18 years) patients with a history of grass and birch pollen allergy verified by positive skin prick test and allergen-specific IgE in blood. The study population may also include patients with ongoing or completed AIT.

You may qualify if:

• History of allergic rhinitis, conjunctivitis or asthma due to sensitization to grass- or birch Allergens
• Male or female patients older than 18 years
• Written informed consent for providing blood and also to allow experimental manipulation

You may not qualify if:

• Age \< 18 years
• Any corticosteroids within the last three days
• Oral corticosteroid therapy within the last ten days
• Parenteral depot corticosteroids within the last three months

Sponsors & Collaborators

• Mabylon AG: lead

Study Sites (1)

Immunologie Zentrum Zürich

Zurich, Canton of Zurich, 8006, Switzerland

Location

MeSH Terms

Conditions

Rhinitis, Allergic, Seasonal

Condition Hierarchy (Ancestors)

Rhinitis, Allergic; Rhinitis; Nose Diseases; Respiratory Tract Diseases; Respiratory Hypersensitivity; Otorhinolaryngologic Diseases; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 31, 2018
• First Posted: November 1, 2018
• Study Start: October 1, 2018
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: May 2, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)