Movement Disorders and Early Maladaptive Schemas

NCT03717376 | Completed

• 1 other identifier: NI18039J
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Functional neurological disorders (FND) are neurological symptoms that cannot be explained by a lesion or related to an identified dysfunction of the central nervous system. FND are under-diagnosed, although common and highly disabling. Childhood trauma events are found in 30% to 80% of FND patients, and are more common in people with functional neurological disorder than in healthy controls and patient controls. Overall, risks factors, perpetuating factors and maintaining factors have been described in FND, although none of the studies have analysed the prevalence of Early Maladaptive Schemas (EMS) in these patients. EMS, as measured with the Young Schema Questionnaire (YSQ), are proposed to underlie a variety of mental health problems, in particular Personality Disorders. We hypothesize that some of these early maladaptive schemas may participate in the psychopathology and severity of FND. The main outcome of this study is to assess the prevalence of early maladaptive schemas in patients presenting with Functional Movement Disorders in comparison to patients presenting with Parkinson's Disease or Organic Dystonia. The secondary outcomes are to further analyse the underlying relation of these early maladaptive schemas and (i) the severity of the motor symptoms, (ii) anxiety and/or depression, (iii) the occurrence of childhood trauma events in our participants.

Conditions

Functional Movement Disorder; Parkinson Disease; Dystonic Disorders

Keywords

Functional Movement Disorder; Functional Neurological Disorder; Early Maladaptive Scheme; Parkinson; Dystonia

Outcome Measures

Primary Outcomes (1)

• Assessment of the prevalence of early maladaptive schemas in patients with Functional Movement Disorders versus patients with Parkinson's Disease or Dystonic Disorders

  Score ≥16 in each schema on the Young Schema Questionnaire-S3 (YSQ-S3) is considered as pathological

  Through study completion, an average of 1 year

Secondary Outcomes (3)

• Correlation between the YSQ-S3 scores and the severity of motor symptoms (score from the Unified Parkinson's Disease Rating Scale (UPDRS) part 3)

  Through study completion, an average of 1 year

• Correlation between the YSQ-S3 scores and anxiety/depression symptoms (screened with the Hospital Anxiety and Depression Scale (HADS) together with the Mini International Neuropsychiatric Interview (MINI))

  Through study completion, an average of 1 year

• Correlation between the YSQ-S3 scores and self-reported childhood traumatic events (assessed with the Composite International Diagnosis Interview (CIDI) questionnaire)

  Through study completion, an average of 1 year

Interventions

Self-questionnaire YSQ-S3 (Young Schema Questionnaire) OTHER

All participants will fill the YSQ-S3 at home and send it back to the main investigator.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients followed-up at Pitié-Salpêtrière hospital with functional movement disorder, parkinson's disease or distonic disorders.

You may qualify if:

• Age ≥ 18 years-old
• Being diagnosed with Parkinson's Disease (United Kingdom Parkinson's Disease Society Brain Bank (UKPDSBB) criteria) or with Functional Movement Disorder (Gupta \& Lang criteria) or with Dystonia (criteria from Obeso et al. Mov Dis 2013)
• Being previously included in the research protocol untitled " Retentissement des mouvements anormaux "
• Patient informed and having given their non-opposition
• Written and oral comprehension of French

You may not qualify if:

• Pregnancy
• Guardianship or Tutelage measure
• Psychosis
• Other neurological disorder (i.e.: brain tumor, ...)

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead

Study Sites (1)

APHP - Pitié-Salpêtrière hospital

Paris, 75013, France

Location

MeSH Terms

Conditions

Conversion Disorder; Parkinson Disease; Dystonic Disorders; Dystonia

Condition Hierarchy (Ancestors)

Somatoform Disorders; Mental Disorders; Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases; Dyskinesias; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Richard LEVY, MD. PhD

  Assistance Publique Hoptiaux de Paris

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 15, 2018
• First Posted: October 24, 2018
• Study Start: February 12, 2019
• Primary Completion: February 12, 2019
• Study Completion: February 12, 2020
• Last Updated: January 31, 2022

Record last verified: 2021-02

Locations

FR (1)