Autocorrelated Rhythmic Auditory Stimulations for Parkinson's Disease Patients

NCT03716674 | Completed

• 1 other identifier: NMSK - Lheureux - 01
• Study Type: interventional
• Target: 9
• Locations: 0 countries
• Sites: N/A

Brief Summary

Parkinson's Disease (PD) patients suffer from gait impairments responsible for falls and bad quality of life: reduced speed and stride length, randomness in stride duration variability (reduced Long-Range Autocorrelations (LRA)). Authors showed beneficial effects of isochronic Rhythmic Auditory Stimulation (RAS) on stride length and speed but a deleterious effect on LRA. The aim of this prospective cohort study was to compare between 3 different RAS (isochronic, random and autocorrelated) on 9 PD patients' gait parameters and stride duration variability. Although the autocorrelated RAS (AC) does not improve the LRA present in the stride duration variability, the AC does, however, maintain an acceptable level of LRA for PD patients' gait stability. The autocorrelated RAS would therefore possibly be the best way to apply auditory cueing to PD patients but this must be confirmed by future longitudinal studies.

Conditions

Parkinson Disease

Keywords

Parkinson's Disease; rhythmic auditory stimulation; cueing; Long-Range Autocorrelations

Outcome Measures

Primary Outcomes (1)

• Long-Range Autocorrelations

  Change from baseline in long-range autocorrelations during each intervention condition (2 days, 2 x 10 min walking each day)

Secondary Outcomes (4)

• Mean gait speed

  Change from baseline in mean gait speed during each intervention condition (2 days, 2 x 10 min walking each day)

• Step length

  Change from baseline in step length during each intervention condition (2 days, 2 x 10 min walking each day)

• Gait cadence

  Change from baseline in gait cadence during each intervention condition (2 days, 2 x 10 min walking each day)

• Coefficient of variation of stride duration

  Change from baseline in coefficient of variation during each intervention condition (2 days, 2 x 10 min walking each day)

Study Arms (1)

Parkinson's Disease patients

EXPERIMENTAL

Device: Metronome

Interventions

Metronome DEVICE

Patients completed 4 walking sessions of at least 10 minutes each. During each session, no auditory rhythm was given, or the rhythm of a Rhythmic Auditory Stimulation (RAS) adapted to the pace of comfort of each patient using a metronome was broadcasted via headphones. In all, 4 conditions were tested: walk with no RAS or an isochronous RAS or a random RAS or a RAS with an autocorrelated metronome rhythm.

Parkinson's Disease patients

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Idiopathic Parkinson's Disease according to UK Brain Bank criteria
• A modified Hoehn \& Yahr scale between 1 and 3
• Able to walk for at least 10 minutes in a row
• Dopaminergic was stable for a minimum of 4 weeks before the study starts
• A Mini-Mental State Examination (MMSE) \>24

You may not qualify if:

• Severe co-morbidity, other neurological problems, acute medical problems (e.g. MI, diabetes) and joint problems affecting mobility
• Unpredictable "Off"-periods (score \>2, MDS-UPDRS item 4.5)

Sponsors & Collaborators

• Cliniques universitaires Saint-Luc- Université Catholique de Louvain: lead

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: This was a cross-sectional study
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professor

Model Details: A single group of 9 patients completed the 4 conditions presented in the Methods section.

Study Record Dates

• First Submitted: August 31, 2018
• First Posted: October 23, 2018
• Study Start: February 2, 2015
• Primary Completion: February 19, 2015
• Study Completion: February 19, 2015
• Last Updated: October 23, 2018

Record last verified: 2018-10

Data Sharing

• IPD Sharing: Will not share