PEEP Levels on Intraabdominal Pressure and Hemodynamics in Critically Ill Patients

NCT03714724 | Completed

• 1 other identifier: PEEP and IAP
• Study Type: interventional
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, it was aimed to compare the effects of three different PEEP levels (0-4, 5-8, 9-12 cmH2O) on intraabdominal pressure and hemodynamic parameters of patients in intensive care unit.

Conditions

Intraabdominal Hypertension; Critically Ill; Hemodynamic Instability

Keywords

Critically ill patients; intraabdominal pressure; hemodynamics; positive end-expiratory pressure

Outcome Measures

Primary Outcomes (1)

• measure intraabdominal pressure

  Intraabdominal Pressure Measurement In this method, a sterile set system (AbViser- Wolfe Tory Medical, Saik Lake City, Utah, USA) was used in normal conditions. Measurements will be made in 20 ml saline was given, Pressure transducer was used as a reset point pubic symphysis and intra-abdominal pressure was measured.

  1 month

Study Arms (3)

Group 4

ACTIVE COMPARATOR

Patients who received 0-4 cmH2O PEEP in mechanical ventilation were referred to as Group 4. Intraabdominal, central venous, arterial blood pressures, pulse rates, peripheric oxygen saturation, body temperature, instant fluid balances and amounts of urine (in ml/kg/hour unit) of the patients were measured on the 0. 6. 12. 18. and 24. hours and recorded.

Diagnostic Test: Intraabdominal Pressure Measurement

Group 8

ACTIVE COMPARATOR

Patients who received 5-8 cmH2O PEEP in mechanical ventilation were referred to as Group 8. Intraabdominal, central venous, arterial blood pressures, pulse rates, peripheric oxygen saturation, body temperature, instant fluid balances and amounts of urine (in ml/kg/hour unit) of the patients were measured on the 0. 6. 12. 18. and 24. hours and recorded.

Diagnostic Test: Intraabdominal Pressure Measurement

Group 12

ACTIVE COMPARATOR

Patients who received 9-12 cmH2O PEEP in mechanical ventilation were referred to as Group 12. Intraabdominal, central venous, arterial blood pressures, pulse rates, peripheric oxygen saturation, body temperature, instant fluid balances and amounts of urine (in ml/kg/hour unit) of the patients were measured on the 0. 6. 12. 18. and 24. hours and recorded.

Diagnostic Test: Intraabdominal Pressure Measurement

Interventions

Intraabdominal Pressure Measurement DIAGNOSTIC_TEST

In this method, a sterile set system (AbViser- Wolfe Tory Medical, Saik Lake City, Utah, USA) was used in normal conditions. Measurements will be made in 20 ml saline was given, Pressure transducer was used as a reset point pubic symphysis and intra-abdominal pressure was measured.

Group 12; Group 4; Group 8

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• age between 18-80,
• connected to mechanical ventilator in intensive care,
• had not undergone surgery of the abdomen,
• patients followed at the same PEEP levels for at least 24 hours

You may not qualify if:

• The consent for the study,
• initial intrabdominal pressure level is over 12 cmH2O,
• undergoing abdominal surgery or bladder surgery,
• neurogenic bladder,
• morbid obesity,
• Chronic Obstructive Pulmonary Disease Patients were excluded from the study.

Sponsors & Collaborators

• Yuzuncu Yil University: lead

Study Sites (1)

Van yuzuncu Yıl University, Dursun Odabas Medical Center

Van, 65080, Turkey (Türkiye)

Location

Related Publications (2)

• Marini M, Caretta G, Vagnarelli F, Luca F, Biscottini E, Lavorgna A, Procaccini V, Riva L, Vianello G, Aspromonte N, Mortara A, De Maria R, Capasso P, Valente S, Gulizia MM. [Hemodynamic effects of positive end-expiratory pressure]. G Ital Cardiol (Rome). 2017 Jun;18(6):505-512. doi: 10.1714/2700.27611. Italian.

  PMID: 28631764 RESULT

• Verzilli D, Constantin JM, Sebbane M, Chanques G, Jung B, Perrigault PF, Malbrain M, Jaber S. Positive end-expiratory pressure affects the value of intra-abdominal pressure in acute lung injury/acute respiratory distress syndrome patients: a pilot study. Crit Care. 2010;14(4):R137. doi: 10.1186/cc9193. Epub 2010 Jul 21.

  PMID: 20663183 RESULT

MeSH Terms

Conditions

Intra-Abdominal Hypertension; Critical Illness

Condition Hierarchy (Ancestors)

Compartment Syndromes; Muscular Diseases; Musculoskeletal Diseases; Vascular Diseases; Cardiovascular Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Nureddin Yüzkat

  Yuzuncu Yil University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor

Model Details: Intraabdominal pressure of the patients were measured on the 0. 6. 12. 18. and 24. hours and recorded.

Study Record Dates

• First Submitted: October 17, 2018
• First Posted: October 22, 2018
• Study Start: February 1, 2018
• Primary Completion: October 1, 2018
• Study Completion: October 10, 2018
• Last Updated: October 22, 2018

Record last verified: 2018-10

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)