Procalcitonin at Zero and 24 Hours as a Prognostic Factor in Patients With Pneumonia

NCT03711227 | Completed

• 1 other identifier: MMMC#1577
• Study Type: observational
• Target: 185
• Locations: 1 country
• Sites: 1

Brief Summary

Procalcitonin levels checked initially and at 24 hours will correlate with disease severity, morbidity, and mortality. Patients who have a higher procalcitonin level initially and at 24 hours will likely have higher qSOFA scores, longer lengths of stay, longer duration of antibiotics and higher 30 day mortality rates.

Conditions

Pneumonia

Keywords

Serial Procalcitonin, Admitted Pneumonia, qSOFA, Sepsis

Outcome Measures

Primary Outcomes (1)

• Change in Procalcitonin level

  Change in procalcitonin level in the blood serum

  Measured at baseline and at 24 hours

Secondary Outcomes (4)

• qSOFA score

  baseline and at 24 hours

• Length of stay

  an average of 30 days

• Duration of antibiotics

  an average of 30 days

• 30 Day Mortality

  30 days

Study Arms (1)

Procalcitonin lab test

A procalcitonin order bundle will be created for admitted patients with pneumonia. This prepopulated bundle includes an initial and 24 hour procalcitonin level. These patients will receive treatment for their pneumonia as is deemed appropriate by their care teams, both in the Emergency Department and while an inpatient. Then, after discharge, the 30 day mortality, length of stay, choice of antibiotic therapy, and qSOFA score (which will be retroactively calculated) will be compared to the patient's initial and 24 hour procalcitonin level.

Diagnostic Test: Procalcitonin lab test

Interventions

Procalcitonin lab test DIAGNOSTIC_TEST

A procalcitonin order bundle will be created for admitted patients with pneumonia. This prepopulated bundle includes an initial and 24 hour procalcitonin level.

Procalcitonin lab test

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients seen at Lakeland St. Joseph and Niles Hospitals in the emergency department and who are then subsequently admitted with pneumonia at Lakeland St. Joseph and Niles Hospitals

You may qualify if:

• All patients seen at Lakeland St. Joseph and Niles Hospitals in the emergency department and who are then subsequently admitted with pneumonia at Lakeland St. Joseph and Niles Hospitals

You may not qualify if:

• Any patients not admitted with pneumonia, any patients who are admitted with another primary diagnosis other than pneumonia, any patients who do not have an initial or 24 hour procalcitonin level result, and any patients less than 18 years old

Sponsors & Collaborators

• Corewell Health South: lead
• Michigan State University: collaborator

Study Sites (1)

Lakeland Regional Healthcare

Saint Joseph, Michigan, 49085, United States

Location

Related Publications (22)

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MeSH Terms

Conditions

Pneumonia; Sepsis

Condition Hierarchy (Ancestors)

Respiratory Tract Infections; Infections; Lung Diseases; Respiratory Tract Diseases; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Michelino Mancini, DO

  Lakeland Hospitals at St. Joseph and Niles

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 2, 2018
• First Posted: October 18, 2018
• Study Start: July 17, 2018
• Primary Completion: August 1, 2019
• Study Completion: August 1, 2019
• Last Updated: November 29, 2024

Record last verified: 2019-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)