Weight Bearing Exercise in Preventing Frailty in Stage I-IIIA Breast Cancer Survivors

NCT03708055 | Completed DMC

• 3 other identifiers: 0800000618NCI-2018-01888P30CA023074
• Study Type: interventional
• Target: 27
• Locations: 1 country
• Sites: 1

Brief Summary

This trial studies how well weight bearing exercise works in preventing frailty in stage I-IIIA breast cancer survivors. Weight bearing exercise, including muscle-strengthening, aerobic, flexibility, and balance exercises, can decrease fat and increase muscle, which may lead to reduced frailty.

Conditions

Anatomic Stage I Breast Cancer AJCC v8; Anatomic Stage IA Breast Cancer AJCC v8; Anatomic Stage IB Breast Cancer AJCC v8; Anatomic Stage II Breast Cancer AJCC v8; Anatomic Stage IIA Breast Cancer AJCC v8; Anatomic Stage IIB Breast Cancer AJCC v8; Anatomic Stage IIIA Breast Cancer AJCC v8; Cancer Survivor; Overweight; Postmenopausal; Prognostic Stage I Breast Cancer AJCC v8; Prognostic Stage IA Breast Cancer AJCC v8; Prognostic Stage IB Breast Cancer AJCC v8; Prognostic Stage II Breast Cancer AJCC v8; Prognostic Stage IIA Breast Cancer AJCC v8; Prognostic Stage IIB Breast Cancer AJCC v8; Prognostic Stage IIIA Breast Cancer AJCC v8

Outcome Measures

Primary Outcomes (4)

• Reproducibility of muscle activation by subcutaneous fat mass measures.

  Demonstrate reproducibility of forearm muscle activation and subcutaneous fat measures in a healthy convenience sample/population (N= 10). Standard anthropometric measurements (height, weight, waist, hip and arm circumferences) will be taken at baseline and 8weeks. A total body dual energy X-ray absorptiometry (DXA) scan, with an effective radiation dose of about 0.01 mSv, which is about the same as background radiation in one day according to the American College of Radiology (http://www.radiologyinfo.org/en/safety/index.cfm?pg=sfty\_xray#3), will be used to determine fat mass and fat free mass at these same time-points. Skeletal muscle mass will be determined by using both appendicular lean mass/height2 method and the residuals model from the Health ABC Study.

  Up to 9 years

• Amount of lean muscle as determined by using both appendicular lean mass/height2 method and the residuals model from the Health ABC Study.

  Skeletal muscle mass will be determined by using both appendicular lean mass/height2 method and the residuals model from the Health ABC Study.

  8 weeks

• Reproducibility of signal attenuation using electromyography (EMG)

  Maximal isometric muscle activation of the forearm flexors by electromyography (EMG) will be assessed by a pair of surface electrodes (plus 1 ground), to minimize participant burden. EMG data will be amplified and recorded by BIOPAC Systems MP35, 4-channel acquisition system and BSL Pro 3.7 software (BIOPAC Systems, Inc. Goleta, CA), during each of 4, 2-second, repetitions on the 100kg hand grip isometric dynamometer, integrated into the BIOPAC system. Sampling rate and acquisition length will be standardized. The I-beam tool will select the initiation of and conclusion of each contraction. Contraction 1 for each participant will be used for exercise familiarization and dropped, contractions 2-4 will be averaged to for maximal isometric muscle activation (mV). Normally, the non-dominant arm would be evaluated, but since this particular population may have functional limitations on either or both sides due to surgery (i.e. lymphectomy or mastectomy), both arms will be measured.

  Up two weeks

• Level of strength as measured by 8-12 repetition maximum (RM) and by hand grip dynamometer.

  A standard submaximal test of strength, 8-12 repetition maximum (RM) will used to evaluate strength and maintain loads in the lower body, which has been safe and effective in previous studies. Strength by hand grip dynamometer will also be measured at baseline and 8wks post-training.

  Up to 8 weeks

Other Outcomes (2)

• Measure changes in biomarkers, i.e. insulin resistance, inflammatory cytokines (such as IL-6, CRP and others), and growth factors (such as myostatin, IGF-1, IGFBP-3 and others).

  Up to 8 weeks

• Quantitative and qualitative analysis of DNA.

  Up to 8 weeks

Study Arms (1)

Prevention (weight bearing exercise program)

EXPERIMENTAL

Participants undergo a weight bearing exercise program in a group 2 days a week and at home 5 days a week for 8 weeks.

Behavioral: Exercise Intervention

Interventions

Exercise Intervention BEHAVIORAL

Undergo weight bearing exercise program

Prevention (weight bearing exercise program)

Eligibility Criteria

• Age: 37 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Post-menopausal (12 months without menstrual period: naturally, surgically, by hormone suppression).
• History of early stage breast cancer (stage I, II, IIIa).
• At least 6 months from chemotherapy.
• May be receiving hormonal therapy during the study.
• Currently disease-free, including a negative mammogram within 1 year.
• Body mass index (BMI) between 25 and 40kg/m\^2.
• In general good health with no acute or chronic disease that could worsen with weight bearing exercise.
• Not currently on a prescribed diet nor reporting weight loss of \> 10 pounds (lbs) in previous 3 months.
• Not currently participating in physical activity (PA) independently or a structured program (performing \< 120 min of low-intensity, low-impact exercise per week; and no weightlifting or similar physical activity).
• Ability to participate in physical activity, not limited by severe disability (e.g., severe arthritic conditions); chronic back pain, or history or presence of diseases for which increased physical activity would not be advised.
• No severe chronic disease, other than breast cancer (e.g., human immunodeficiency virus/acquired immunodeficiency syndrome \[HIV/AIDS\], kidney failure, liver failure, chronic obstructive pulmonary disease, congestive heart failure, Alzheimer?s, unstable angina, uncontrolled asthma, uncontrolled diabetes, uncontrolled hypertension).
• No implanted cardiac pacemaker, cardiac defibrillator, or other implanted electronic medical equipment.
• No history of drug or alcohol abuse.
• Able to remain in a lying or sitting position for an extended period (\> 30 minutes).
• No history or presence of a significant psychiatric disorder or any other condition that would interfere with participation in the trial.

Sponsors & Collaborators

• University of Arizona: lead
• National Cancer Institute (NCI): collaborator

Study Sites (1)

The University of Arizona Medical Center-University Campus

Tucson, Arizona, 85724, United States

Location

MeSH Terms

Conditions

Overweight

Condition Hierarchy (Ancestors)

Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Jennifer Bea

  The University of Arizona Medical Center-University Campus

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 9, 2018
• First Posted: October 16, 2018
• Study Start: July 24, 2008
• Primary Completion: April 4, 2017
• Study Completion: April 4, 2017
• Last Updated: October 23, 2018

Record last verified: 2018-10

Locations

US (1)