Evaluation of Mitochondrial Function in Myofascial Trigger Points Cohort Pilot Study Using High-resolution Respirometry

NCT03704311 | Completed

• 1 other identifier: MUInnsbruck
• Study Type: interventional
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

This pilot study established a minimally invasive biopsy technique to obtain high-quality MTrP tissue samples to evaluate mitochondrial function via high-resolution respirometry.

Conditions

Pain, Neck; Pain, Back; Myofascial Trigger Point Pain; Myofascial Pain; Mitochondrial Pathology

Outcome Measures

Primary Outcomes (1)

• Mitochondrial function in myofascial trigger points

  Mitochondrial respiration was assessed from muscle biopsy samples obtained from trigger points of the musculus trapezius and the musculus gluteus medius

  Baseline measurement

Secondary Outcomes (1)

• Number of participants with biopsy-related impaired wound healing

  Baseline and follow-up assessment (1 week after the baseline biopsy)

Study Arms (1)

Single

EXPERIMENTAL

Evaluation of mitochondrial function after muscle biopsy and follow-up for surgical complications.

Procedure: Muscle biopsy

Interventions

Muscle biopsy PROCEDURE

Local anesthesia was applied to the superficial skin covering the MTrP of each participant. Percutaneous biopsy sampling optimized with a suction-enhancement technique was used to obtain muscle biopsies of the m. trapezius MTrP or the m. gluteus medius MTrP from each participant using small Bergstrom muscle biopsy needle, 8 swg (4.0mm) x 100 mm (Dixons Surgical Instruments, Essex, United Kingdom).

Single

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Male patients aged 18-45 years
• Clinical diagnosis of myofascial pain syndrome within the region of the shoulder-neck muscles or the lumbogluteal region and the presence of an MTrP, defined as a firm palpation of a hard, tender nodule resulting in a spontaneous pain complaint
• with symptoms present for 1 to 12 months

You may not qualify if:

• Signs that the participant's prescriptive compliance was not expected (e.g., lack of cooperation)
• Disorders of the respiratory tract
• Neurological disorders, in particular neurodegenerative and neuromuscular diseases
• Disorders of the cardiovascular system or the musculoskeletal system
• Civil servants and military service personnel.

Sponsors & Collaborators

• Medical University Innsbruck: lead

Related Publications (1)

• Fischer MJ, Horvath G, Krismer M, Gnaiger E, Goebel G, Pesta DH. Evaluation of mitochondrial function in chronic myofascial trigger points - a prospective cohort pilot study using high-resolution respirometry. BMC Musculoskelet Disord. 2018 Oct 30;19(1):388. doi: 10.1186/s12891-018-2307-0.

  PMID: 30376863 DERIVED

MeSH Terms

Conditions

Neck Pain; Back Pain; Myofascial Pain Syndromes

Condition Hierarchy (Ancestors)

Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Muscular Diseases; Musculoskeletal Diseases

Study Officials

• Michael J Fischer, MD, PhD

  Medical University Innsbruck

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: Assessor doing high Resolution respirometry was blinded with respect to diagnosis, location of biopsy and all Patient related data
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 9, 2018
• First Posted: October 12, 2018
• Study Start: October 1, 2013
• Primary Completion: February 1, 2014
• Study Completion: December 1, 2014
• Last Updated: October 12, 2018

Record last verified: 2018-10

Data Sharing

• IPD Sharing: Will not share