Speckle-Tracking and Volume Expansion

NCT03702569 | Completed

• 1 other identifier: CHUBX 2018/19
• Study Type: observational
• Target: 77
• Locations: 1 country
• Sites: 1

Brief Summary

Volume expansion is the cornerstone of hemodynamic management of patients suffering from circulatory failure. The main objective of volume expansion is to increase stroke volume. This increase in stroke volume is due to myocardial contractility improvement. Nowadays, this improvement cannot be assessed using classical monitoring used at the bedside. The main objective of this study is to evaluate left ventricular contractility using Speckle-Tracking before and after volume expansion in intensive care unit patients, to determine if this technology is more sensitive than previous for left ventricular contractility assessment.

Conditions

Volume Expansion; Left Ventricular Contractility

Keywords

Volume Expansion; Intensive Care Unit; Left Ventricular Contractility; Speckle Tracking; STRAIN

Outcome Measures

Primary Outcomes (4)

• Left ventricular Global Longitudinal Strain

  It is calculated using values of longitudinal strain measured in the three-,four-, and two-chamber of the left ventricle of the heart. GLS is expressed as percentage. Strain is a measure of myocardial muscle fiber shortening during contraction and is calculated as the systolic segment shortening between end-systolic (ES) segment length (L) and end-diastolic (ED) length: strain = (-LES - LED)/LED x 100 %.

  3 minutes before the beginning of volume expansion of 500ml of crystalloid

• Left ventricular Global Longitudinal Strain

  It is calculated using values of longitudinal strain measured in the three-,four-, and two-chamber of the left ventricle of the heart. GLS is expressed as percentage. Strain is a measure of myocardial muscle fiber shortening during contraction and is calculated as the systolic segment shortening between end-systolic (ES) segment length (L) and end-diastolic (ED) length: strain = (-LES - LED)/LED x 100 %.

  3 minutes after the beginning of volume expansion of 500ml of crystalloid

• Stroke volume

  3 minutes before the beginning of volume expansion of 500ml of crystalloid

• Stroke volume

  3 minutes after the beginning of volume expansion of 500ml of crystalloid

Study Arms (1)

Patients needing a volume expansion

Diagnostic Test: Left ventricular global longitudinal strain measure

Interventions

Left ventricular global longitudinal strain measure DIAGNOSTIC_TEST

Left ventricular global longitudinal strain value measured before and immediately after volume expansion (500mL crystalloid) using speckle tracking images with echocardiography

Patients needing a volume expansion

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patient older than 18 years hospitalized in neuro-intensive care unit of Bordeaux University Hospital needing volume expansion.

You may qualify if:

• patient older than 18 years
• hospitalized in neuro-intensive care unit
• volume expansion indicated by the physician
• indication of a transthoracic echocardiography

You may not qualify if:

• low echogenicity

Sponsors & Collaborators

• University Hospital, Bordeaux: lead

Study Sites (1)

CHU de Bordeaux

Bordeaux, 33076, France

Location

MeSH Terms

Conditions

Sprains and Strains

Condition Hierarchy (Ancestors)

Wounds and Injuries

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 4, 2018
• First Posted: October 11, 2018
• Study Start: November 20, 2018
• Primary Completion: February 17, 2021
• Study Completion: February 17, 2021
• Last Updated: November 5, 2021

Record last verified: 2021-11

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)