Betaine Effect in Speed-strength Athletes

NCT03702205 | Unknown Phase 2

• 1 other identifier: ULS00005
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

The study is aimed at assessing the influence of two betaine doses (2.5 g∙d-1 and 5 g∙d-1) supplemented for three weeks in a group of speed-strength trained athletes on anaerobic capacity in Wingate test, performance in CrossFit-like exercise test - Fight Gone Bad, alterations in body compositions and total body water.

Conditions

Supplementation; Sport

Outcome Measures

Primary Outcomes (3)

• Changes in fat mass and fat free mass after betaine supplementation

  Fat mass (kg) and fat free mass (kg) analysis

  Baseline and after 3 weeks

• Changes in anaerobic capacity after betaine supplementation

  The Wingate cycling test (W)

  Baseline and after 3 weeks

• Changes in specific performance capacity after betaine supplementation

  The CrossFit-specific physical fitness test: Fight Gone Bad (reps.)

  Baseline and after 3 weeks

Secondary Outcomes (6)

• Changes in total body water after betaine supplementation

  Baseline and after 3 weeks

• Changes in testosterone level (ng/L) after betaine supplementation

  Baseline and after 3 weeks

• Changes in amino acid profile after betaine supplementation

  Baseline and after 3 weeks

• Changes in blood betaine

  Baseline and after 3 weeks

• Changes in total, LDL and HDL cholesterol and triacylglycerol after betaine supplementation

  Baseline and after 3 weeks

Study Arms (2)

Betaine supplementation

EXPERIMENTAL

The experimental procedure for each athlete includes a 3-week betaine supplementation either 2.5 g or 5 g daily. Betaine will be administered in the form of capsules containing either 0.5 or 1 g betaine. The capsules will be ingested with at least 250 mL of water. Each athlete will ingest 5 betaine capsules a day. On training days the supplements will be taken in the morning (2 capsules), in the evening (2 capsules) and 1.5 hours before training session (1 capsule). On rest days the supplements will be taken in the morning (2 capsules), in the afternoon (1 capsule) and in the evening (2 capsules).

Dietary Supplement: Betaine supplementation; Dietary Supplement: Placebo treatment

Placebo treatment

EXPERIMENTAL

The experimental procedure for each athlete included a 3-week placebo administration. Placebo will be capsules with starch. Placebo will be ingested with at least 250 mL of water. Each athlete will ingest 5 placebo capsules a day. On training days the supplements will be taken in the morning (2 capsules), in the evening (2 capsules) and 1.5 hours before training session (1 capsule). On rest days the supplements will be taken in the morning (2 capsules), in the afternoon (1 capsule) and in the evening (2 capsules).

Dietary Supplement: Betaine supplementation; Dietary Supplement: Placebo treatment

Interventions

Betaine supplementation DIETARY_SUPPLEMENT

Group taking oral betaine supplementation

Betaine supplementation; Placebo treatment

Placebo treatment DIETARY_SUPPLEMENT

Group taking oral supplementation with placebo (starch) in a similar capsule form.

Betaine supplementation; Placebo treatment

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• written informed consent from all participants before the study
• a current medical clearance to practice sports,
• training experience: at least 1 year (of CrossFit ttraining),
• minimum of 2 workout sessions (combat sport) a week,

You may not qualify if:

• current injury,
• any health-related contraindication,
• declared general feeling of being unwell,
• unwilling to follow the study protocol,
• serious disease or metabolic problems,
• intake of betaine, choline or creatine supplements 4 weeks before the beginning of the study.

Sponsors & Collaborators

• Poznan University of Life Sciences: lead
• National Science Centre, Poland: collaborator

Study Sites (1)

Institute of Human Nutrition and Dietetics, Poznan University of Life Sciences

Poznan, 60-624, Poland

RECRUITING

Related Publications (1)

• Zawieja E, Durkalec-Michalski K, Sadowski M, Glowka N, Chmurzynska A. Betaine supplementation improves CrossFit performance and increases testosterone levels, but has no influence on Wingate power: randomized crossover trial. J Int Soc Sports Nutr. 2023 Dec;20(1):2231411. doi: 10.1080/15502783.2023.2231411.

  PMID: 37409757 DERIVED

Study Officials

• Agata Chmurzyńska, Professor

  Institute of Human Nutrition and Dietetics, Poznan University of Life Sciences, Poznan, Poland

  STUDY DIRECTOR

Central Study Contacts

Emilia E Zawieja, MSc

CONTACT

+48 61 846 60 57; emilia.zawieja@up.poznan.pl

Krzysztof Durkalec-Michalski, PhD

CONTACT

+48 618 487 338; durkmich@up.poznan.pl

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 8, 2018
• First Posted: October 10, 2018
• Study Start: October 15, 2018
• Primary Completion: June 20, 2021
• Study Completion: October 12, 2021
• Last Updated: September 16, 2020

Record last verified: 2020-09

Locations

PL (1)