Physical Impairments Related to Myeloid and Lymphoid Malignancies

NCT03699358 | Completed

• 1 other identifier: GaziUniversity15
• Study Type: observational
• Target: 57
• Locations: 1 country
• Sites: 1

Brief Summary

Hematologic malignancies may arise from myeloid and lymphoid blood cells lineages affecting blood, bone marrow and lymph nodes. Accordingly, negative effects of malignancies on body systems vary. As known, muscle strength, exercise capacity, fatigue and quality of life deteriorate during allogeneic hematopoietic stem cell transplantation (HSCT). However, impacts of myeloid and lymphoid type disorders on pulmonary functions, muscle strength, exercise capacity, fatigue and quality of life in allogeneic-HSCT who diagnosed with hematologic malignancies. Therefore, current study aimed to comparatively investigate physical impairments between recipients with hematologic malignancies according to myeloid and lymphoid type disorder.

Conditions

Stem Cell Transplantation

Keywords

hematopoietic stem cell transplantation; respiratory function test; respiratory muscles; muscle strength; exercise; walk test; quality of life

Outcome Measures

Primary Outcomes (1)

• Maximal exercise capacity evaluation

  Modified-Incremental Shuttle Walk Test (ISWT) test was used to evaluate maximal exercise capaciity.

  15-20 minutes

Secondary Outcomes (4)

• pulmonary function test

  5 minutes

• Inspiratory and expiratory muscle strength (MIP, MEP)

  5-10 minutes

• Quadriceps femoris muscle strength

  5 minutes

• Quality of life level

  2 minutes

Study Arms (2)

Group 1: Myeloid recipients

Patients diagnosed with hematologic malignancy were recipients who undergone allogeneic-HSCT. Recipients were included in the current study and grouped as myeloid and lymphoid according to origin of their diagnosis. Recipients who had myeloid type disorders were included in myeloid group as well as recipients who had lymphoid type disorders were included in lymphoid group.

Group 2: Lymphoid recipients

Patients diagnosed with hematologic malignancy were recipients who undergone allogeneic-HSCT. Recipients were included in the current study and grouped as myeloid and lymphoid according to origin of their diagnosis. Recipients who had myeloid type disorders were included in myeloid group as well as recipients who had lymphoid type disorders were included in lymphoid group.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients in Bone Marrow Transplantation Unit of University were referred for participation in rehabilitation program as outpatient to Faculty of Health Science of University, Department of Physiotherapy and Rehabilitation, cardiopulmonary rehabilitation unit. Patients diagnosed with hematologic malignancy were recipients who undergone allogeneic-HSCT. Recipients who had myeloid type disorders were included in myeloid group as well as recipients who had lymphoid type disorders were included in lymphoid group. A physiotherapist conducted all measurements in the same day for all recipients individually.

You may qualify if:

• years of age,
• being an allogeneic-HSCT recipient who was at minimum 100 days status after transplantation
• receiving optimal standard medical therapy including immunosuppressive agents, antibiotics, supplements and other drugs.

You may not qualify if:

• having cognitive disorders, orthopedic or neurological disease with a potential to affect assessment of exercise capacity, visual impairments and mucositis which may prevent measurements, comorbidities such as asthma, chronic obstructive pulmonary disease (COPD), acute respiratory or other infections, acute hemorrhage, low hemoglobin values (≤8 g/L) and low platelet count (≤10.000 mm3).

Sponsors & Collaborators

• Gazi University: lead

Study Sites (1)

Gazi University Faculty of Health Science Department of PhysioTherapy

Ankara, 06560, Turkey (Türkiye)

Location

Related Publications (4)

• Paul KL. Rehabilitation and exercise considerations in hematologic malignancies. Am J Phys Med Rehabil. 2011 May;90(5 Suppl 1):S88-94. doi: 10.1097/PHM.0b013e31820be055.

  PMID: 21765268 BACKGROUND

• Bergenthal N, Will A, Streckmann F, Wolkewitz KD, Monsef I, Engert A, Elter T, Skoetz N. Aerobic physical exercise for adult patients with haematological malignancies. Cochrane Database Syst Rev. 2014 Nov 11;(11):CD009075. doi: 10.1002/14651858.CD009075.pub2.

  PMID: 25386666 BACKGROUND

• Steinberg A, Asher A, Bailey C, Fu JB. The role of physical rehabilitation in stem cell transplantation patients. Support Care Cancer. 2015 Aug;23(8):2447-60. doi: 10.1007/s00520-015-2744-3. Epub 2015 May 14.

  PMID: 25971213 BACKGROUND

• Bargi G, Bosnak Guclu M, Turkoz Sucak AG. Differences in pulmonary and extra-pulmonary characteristics in severely versus non-severely fatigued recipients of allogeneic hematopoietic stem cell transplantation: a cross-sectional, comparative study. Hematology. 2019 Dec;24(1):112-122. doi: 10.1080/10245332.2018.1526441. Epub 2018 Sep 27.

  PMID: 30261831 BACKGROUND

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Gülşah Barğı, PhD

  Gazi University

  STUDY CHAIR

• Meral Boşnak Güçlü, PhD

  Gazi University

  STUDY DIRECTOR

• Gülsan Türköz Sucak, PhD.

  Bahçeşehir University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor

Study Record Dates

• First Submitted: October 5, 2018
• First Posted: October 9, 2018
• Study Start: March 1, 2012
• Primary Completion: April 1, 2017
• Study Completion: August 1, 2017
• Last Updated: July 1, 2019

Record last verified: 2019-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)