Does Myeloid or Lymphoid Origin of Hematologic Neoplasm Affect Pulmonary Functions, Muscle Strength, Exercise Capacity, Fatigue and Quality of Life?
Sponsor study identifier
observational
57
1 country
1
Study Start
March 2012
Actual (reported)Primary Completion
April 2017
Actual (reported)Study Completion
August 2017
Actual (reported)Hematologic malignancies may arise from myeloid and lymphoid blood cells lineages affecting blood, bone marrow and lymph nodes. Accordingly, negative effects of malignancies on body systems vary. As known, muscle strength, exercise capacity, fatigue and quality of life deteriorate during allogeneic hematopoietic stem cell transplantation (HSCT). However, impacts of myeloid and lymphoid type disorders on pulmonary functions, muscle strength, exercise capacity, fatigue and quality of life in allogeneic-HSCT who diagnosed with hematologic malignancies. Therefore, current study aimed to comparatively investigate physical impairments between recipients with hematologic malignancies according to myeloid and lymphoid type disorder.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 2017
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 2012
Actual (reported)April 2017
Actual (reported)August 2017
Actual (reported)October 5, 2018
Actual (reported)October 9, 2018
Actual (reported)Maximal exercise capacity evaluation
Modified-Incremental Shuttle Walk Test (ISWT) test was used to evaluate maximal exercise capaciity.
15-20 minutes
pulmonary function test
5 minutes
Inspiratory and expiratory muscle strength (MIP, MEP)
5-10 minutes
Quadriceps femoris muscle strength
5 minutes
Quality of life level
2 minutes
Patients diagnosed with hematologic malignancy were recipients who undergone allogeneic-HSCT. Recipients were included in the current study and grouped as myeloid and lymphoid according to origin of their diagnosis. Recipients who had myeloid type disorders were included in myeloid group as well as recipients who had lymphoid type disorders were included in lymphoid group.
Patients diagnosed with hematologic malignancy were recipients who undergone allogeneic-HSCT. Recipients were included in the current study and grouped as myeloid and lymphoid according to origin of their diagnosis. Recipients who had myeloid type disorders were included in myeloid group as well as recipients who had lymphoid type disorders were included in lymphoid group.
All patients in Bone Marrow Transplantation Unit of University were referred for participation in rehabilitation program as outpatient to Faculty of Health Science of University, Department of Physiotherapy and Rehabilitation, cardiopulmonary rehabilitation unit. Patients diagnosed with hematologic malignancy were recipients who undergone allogeneic-HSCT. Recipients who had myeloid type disorders were included in myeloid group as well as recipients who had lymphoid type disorders were included in lymphoid group. A physiotherapist conducted all measurements in the same day for all recipients individually.
Gazi University Faculty of Health Science Department of PhysioTherapy
Ankara, 06560, Turkey (Türkiye)
Paul KL. Rehabilitation and exercise considerations in hematologic malignancies. Am J Phys Med Rehabil. 2011 May;90(5 Suppl 1):S88-94. doi: 10.1097/PHM.0b013e31820be055.
Bergenthal N, Will A, Streckmann F, Wolkewitz KD, Monsef I, Engert A, Elter T, Skoetz N. Aerobic physical exercise for adult patients with haematological malignancies. Cochrane Database Syst Rev. 2014 Nov 11;(11):CD009075. doi: 10.1002/14651858.CD009075.pub2.
Gülşah Barğı, PhD
Gazi University
Meral Boşnak Güçlü, PhD
Gazi University
Gülsan Türköz Sucak, PhD.
Bahçeşehir University
57 participants (actual enrollment reported by the registry).
First Submitted
October 5, 2018
First Posted
October 9, 2018
Study Start
March 2012
Actual (reported)Severe Fatigue in Stem Cell Transplantation
Contact the study team to confirm eligibility.
Steinberg A, Asher A, Bailey C, Fu JB. The role of physical rehabilitation in stem cell transplantation patients. Support Care Cancer. 2015 Aug;23(8):2447-60. doi: 10.1007/s00520-015-2744-3. Epub 2015 May 14.
Bargi G, Bosnak Guclu M, Turkoz Sucak AG. Differences in pulmonary and extra-pulmonary characteristics in severely versus non-severely fatigued recipients of allogeneic hematopoietic stem cell transplantation: a cross-sectional, comparative study. Hematology. 2019 Dec;24(1):112-122. doi: 10.1080/10245332.2018.1526441. Epub 2018 Sep 27.
Primary Completion
April 2017
Actual (reported)Study Completion
August 2017
Actual (reported)Last Updated
July 1, 2019
Record last verified: 2019-06
There is not a plan to make individual participant data but when the statistical analyses of all data are made, all results will be shared.
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Source: ClinicalTrials.gov.
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