BLI, NBI or White Light Colonoscopy for Proximal Colonic Adenoma
BNW
Blue Laser Imaging Versus Narrow Band Imaging Versus White Light Imaging for Detection of Adenoma in the Proximal Colon: A Prospective Randomized Study
1 other identifier
interventional
884
1 country
1
Brief Summary
This is a prospective randomised trial comparing the proximal adenoma detection rate and miss rate by blue laser imaging (BLI), narrow band imaging or white light colonoscopy.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Nov 2018
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 27, 2018
CompletedFirst Posted
Study publicly available on registry
October 5, 2018
CompletedStudy Start
First participant enrolled
November 8, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2022
CompletedApril 21, 2022
April 1, 2022
3.2 years
September 27, 2018
April 19, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Proximal adenoma detection rate
proportion of patients with proximal adenoma detected on first examination
one day
Secondary Outcomes (3)
proximal polyp detection rate
one day
proximal adenoma miss rate
one day
proximal polyp miss rate
one day
Study Arms (3)
NBI
EXPERIMENTALTandem colonoscopy with NBI follow by WL
BLI
ACTIVE COMPARATORTandem colonoscopy with BLI follow by WLI
WLI
EXPERIMENTALTandem colonoscopy with WLI follow by WL
Interventions
Eligibility Criteria
You may qualify if:
- Age 40 or above
- scheduled for colonoscopy
You may not qualify if:
- unable to provide informed consent
- have undergone previous colorectal resection,
- personal history of colorectal cancer, inflammatory bowel disease, familial adenomatous polyposis, Peutz-Jeghers syndrome, or other polyposis syndromes.
- Patients who are considered to be unsafe for polypectomy including patients with bleeding tendency and those with severe comorbid illnesses
- poor bowel preparation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- The University of Hong Konglead
- Queen Mary Hospital, Hong Kongcollaborator
Study Sites (1)
Queen Mary Hospital
Hong Kong, Hong Kong
Related Publications (1)
Leung WK, Tsui VWM, Mak LL, Cheung MK, Hui CK, Lam CP, Wong SY, Liu KS, Ko MK, To EW, Guo CG, Lui TK. Blue-light imaging or narrow-band imaging for proximal colonic lesions: a prospective randomized tandem colonoscopy study. Gastrointest Endosc. 2023 Nov;98(5):813-821.e3. doi: 10.1016/j.gie.2023.06.004. Epub 2023 Jun 10.
PMID: 37307902DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
Wai Keung Leung, MD
The University of Hong Kong
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- DIAGNOSTIC
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
September 27, 2018
First Posted
October 5, 2018
Study Start
November 8, 2018
Primary Completion
February 1, 2022
Study Completion
April 1, 2022
Last Updated
April 21, 2022
Record last verified: 2022-04
Data Sharing
- IPD Sharing
- Will not share