Effects of Emotion on Episodic Memory in Typically Developing Children and Children With Williams-Beuren Syndrome

NCT03688516 | Completed

• 1 other identifier: 2017-A03321-52
• Study Type: interventional
• Target: 280
• Locations: 1 country
• Sites: 1

Brief Summary

It's well established in the literature that emotional events are more likely to be remembered than neutral events. Although this Emotional Enhancement of Memory (EEM) has been well demonstrated in the adult literature, little is known about EEM for typically developing children and children with Williams-Beuren syndrome (WBS). In this study, two investigations will be conducted concomitantly: one of EEM in typically developing children and the other of EEM in children with WBS. For this purpose, three behavioral experiments will be established to investigate EEM in this two populations, with the first experiment also including electroencephalography measures. Performances of typically developing children will be compared to young adults, and performances of children with WBS will be compared to control children matched for mental age. Finally, this study aims to bring new knowledge about the interactions between emotion and memory in children, and to better understand cognitive functioning in children with WBS.

Conditions

Mental Disorders

Keywords

emotion; memory; Williams-Beuren syndrome

Outcome Measures

Primary Outcomes (1)

• Manipulation of Valence

  Behavioral measure:number of correct responses (correct recall and correct recognition), evoked potential for EEG only for Experiment 1

  During the presentation of the stimuli or just after the presentation of the stimuli

Secondary Outcomes (6)

• EEG measures

  During the presentation of the stimuli or just after the presentation of the stimuli

• Source memory

  During the presentation of the stimuli or just after the presentation of the stimuli

• Content memory

  During the presentation of the stimuli or just after the presentation of the stimuli

• Spatial memory

  During the presentation of the stimuli or just after the presentation of the stimuli

• Recognition memory

  During the presentation of the stimuli or just after the presentation of the stimuli

Study Arms (2)

Atypical development

EXPERIMENTAL

30 children with Williams-Beuren syndrome will be presented with two tasks of episodic memory, one with visual stimuli and another one with audio-verbal stimuli. Manipulation of valence and modality (negative, positive, neutral) in order to measure influence of emotion on episodic memory:Spatial and recognition memory ans source and content memory. The tasks will be presented one after another with a break of 15 minutes. In both tasks the participants will have to encode the stimuli and then first recall them and second to recognize the encoded stimuli amongst new stimuli. The stimuli will be presented on the computer. The responses will be collected by the experimenter for recall task and by the computer for recognition task. During the recognition task the EEG recording will be done.

Behavioral: Manipulation of valence and modality; Behavioral: Spatial and recognition memory; Behavioral: Source and content memory

Typical development

SHAM COMPARATOR

30 control children matched for mental age will be presented with two tasks of episodic memory, one with visual stimuli and another one with audio-verbal stimuli. Manipulation of valence and modality (negative, positive, neutral) in order to measure influence of emotion on episodic memory:Spatial and recognition memory ans source and content memory. The tasks will be presented one after another with a break of 15 minutes. In both tasks the participants will have to encode the stimuli and then first recall them and second to recognize the encoded stimuli amongst new stimuli. The stimuli will be presented on the computer. The responses will be collected by the experimenter for recall task and by the computer for recognition task. During the recognition task the EEG recording will be done.

Behavioral: Manipulation of valence and modality; Behavioral: Spatial and recognition memory; Behavioral: Source and content memory

Interventions

Manipulation of valence and modality BEHAVIORAL

mnemic task with a phase of encoding negative, positive and neutral stimuli, will be proposed followed by an immediate recovery phase, composed of a recall task followed by a recognition task

Atypical development; Typical development

Spatial and recognition memory BEHAVIORAL

mnemic task with a phase of encoding negative, positive and neutral stimuli, will be proposed followed by an immediate recovery phase, composed of a recall task followed by a recognition task

Atypical development; Typical development

Source and content memory BEHAVIORAL

mnemic task with a phase of encoding negative, positive and neutral stimuli, will be proposed followed by an immediate recovery phase, composed of a recall task followed by a recognition task

Atypical development; Typical development

Eligibility Criteria

• Age: 6 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Children with William-Beuren syndrome
• Genetic diagnosis (CGH-Array or FISH) of microdeletion 7q11.23
• to 18 years old
• Native French speaker
• Typically developing children and healthy adults:
• to 30 years old
• Native French speaker
• Absence of history of neurodevelopmental neurological and psychiatric disease

You may not qualify if:

• Children with William-Beuren syndrome:
• Diagnosis of severe intellectual deficit (Total IQ lower than 40 evaluated with WPPSI-II or WISC-IV)
• Presence of another genetic anomaly
• Presence of vascular; infectious or neurodegenerative disease
• Medication impacting motor and cognitive abilities
• Non-corrected visual and hearing impairment
• Typically developing children and Healthy Adults :
• Diagnosis of severe intellectual deficit (Total IQ lower than 70 evaluated with WPPSI-II or WISC-IV)
• Presence of vascular; infectious or neurodegenerative disease knew by parents or legal representative
• Learning disorders
• History of neurological or psychiatric disease
• Medication impacting motor and cognitive abilities, non-corrected visual and hearing impairment

Sponsors & Collaborators

• Hôpital le Vinatier: lead

Study Sites (1)

Hopital Vinatier

Lyon, Auvergne-Rhône-Alpes, 69678, France

Location

MeSH Terms

Conditions

Mental Disorders; Williams Syndrome

Condition Hierarchy (Ancestors)

Intellectual Disability; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Aortic Stenosis, Supravalvular; Aortic Valve Stenosis; Aortic Valve Disease; Heart Valve Diseases; Heart Diseases; Cardiovascular Diseases; Chromosome Disorders; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Genetic Diseases, Inborn

Study Officials

• DEMILY CAROLINE

  CH LE VINATIER

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 2, 2018
• First Posted: September 28, 2018
• Study Start: June 28, 2018
• Primary Completion: December 15, 2020
• Study Completion: December 15, 2020
• Last Updated: February 9, 2021

Record last verified: 2021-02

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)