Prognostic Value of Complete Blood Count in Severe Infections

NCT03685071 | Unknown

• 1 other identifier: PVCCSFSI
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

Sepsis is a leading cause of hospitalization in pediatric intensive care units, In the last decade, a series of initiatives were implemented that aim not only to improve the understanding of sepsis and the clarity of concepts related to this condition but also to reduce morbidity and mortality due to sepsis through earlier diagnosis and initiation of antibiotic therapy as well as through the provision of specific guidelines for the treatment of pediatric sepsis. Despite these measures and the lower mortality from sepsis in children compared to adult patients, the impact of sepsis in the pediatric population remains high.

Conditions

Infection Systemic

Outcome Measures

Primary Outcomes (1)

• prognosis of outcome in patients suffering from severe infections in PICU by using CBC .

  Complete blood count in children aged between one month and 18 years suffering of infections is enough as prognostic tool and predict the out come or not enough and more investigation will be required by correlation between CBC and the outcome of patients dead or discharge or morbid sequel.

  one year

Interventions

role of CBC as prognostic tool in sepsis. OTHER

Our study will be conducted on children who admitted to PICU in Assuit University Hospital .CBC parameters as TLC , platelet count , and Hb will be evaluated at time of admission , another CBC will be done at 5th day and another one at day of discharge or last one before death. * patients will be classified into three groups according to the outcome(discharge, mortality and has morbidity sequel.) * correlation between the outcome and CBC will be done.

Eligibility Criteria

• Age: 30 Days - 18 Years
• Sex: all
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

* patients will be classified into three groups according to the outcome(discharge, mortality and has morbidity sequel.) * Correlation between the outcome and blood culture will be done. * correlation between the out come AndCRPwill be done. * Then another correlation between the outcome and CBC will be done. * Comparison between the two previous correlations will be done to detect if CBC alone can predict the outcome of the patients.

You may qualify if:

• Age less than 18 years and \> one month .
• patient presented with sepsis defined as suspected source of infection (we defined sepsis using predetermined international sepsis definitions as clinical syndrome with both infection and a systemic inflammatory response) .
• Abnormal leukocyte count \>12×109 /cmm or\<4 × 109/cmm or\>10% immature form.
• patients presented with secondary organ dysfunction.

You may not qualify if:

• Age more than 18 years and age less than one month.
• patient with active bleeding.
• patient who had used anti platelet drugs .
• patient not diagnosed sepsis or septic shock.

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Toxemia

Condition Hierarchy (Ancestors)

Infections

Study Officials

• doaa heshmat

  Assiut University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Khaled Elsayh, proffessor

CONTACT

01005484357; Khaledelsayh@med.au.edu.eg

MOhamed Amir, ass.prof

CONTACT

01005689353; mohamedalamir@med.au.edu.eg

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Study Record Dates

• First Submitted: September 20, 2018
• First Posted: September 26, 2018
• Study Start: December 1, 2018
• Primary Completion: November 30, 2019
• Study Completion: June 1, 2020
• Last Updated: September 26, 2018

Record last verified: 2018-09