Power Production in Older Adults With Knee Osteoarthritis

NCT03680807 | Completed

• 1 other identifier: S60595
• Study Type: observational
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

Knee osteoarthritis is an important cause of functional disabilities at old age. Previous research has demonstrated that individuals with knee osteoarthritis have reduced knee-extensor strength in comparison to healthy individuals. However, rapid power production declines more than strength as a consequence of ageing and is more predictive of functional capacity. However, limited research has investigated whether individuals with knee osteoarthritis have reduced ability to develop strength and power rapidly on top of reduced maximal strength capacities, which is the primary aim of the current study.

Conditions

Osteo Arthritis Knee

Keywords

Knee osteoarthritis; power production; functional capacity

Outcome Measures

Primary Outcomes (1)

• Rate of power development

  Subjects perform a test protocol on a Biodex dynamometer, consisting of isotonic contractions of the leg-extensor muscles. Subjects are instructed to kick as fast as possible against different (relative) loads. The rate of power development (watt/s) is defined as the linear slope of the power-time curve and is measured from the onset of movement till peak power.

  up to 3 months

Secondary Outcomes (7)

• Maximal isometric strength

  up to 3 months

• Maximal isokinetic strength

  up to 3 months

• Stair Climbing performance

  up to 3 months

• Gait speed

  up to 3 months

• 5 repetition sit-to-stand test

  up to 3 months

Study Arms (2)

Older adults with knee osteoarthritis (>50 years)

Diagnostic Test: Muscle function test

Healthy older adults (> 50 years)

Diagnostic Test: Muscle function test

Interventions

Muscle function test DIAGNOSTIC_TEST

Power and strength tests of the knee-extensor muscles, handgrip strength, functional capacity tests

Healthy older adults (> 50 years); Older adults with knee osteoarthritis (>50 years)

Eligibility Criteria

• Age: 50 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults between 50 and 80 years with or without knee osteoarthritis. Subjects are sedentary or recreationally active.

You may qualify if:

• Group with knee osteoarthritis:
• \- Diagnosed with knee osteoarthritis based on RX.

You may not qualify if:

• Healthy group:
• Systematic engagement in (resistance) exercise in the 12-months prior to participation
• Cardiovascular disease
• Neurological disorders
• Cognitive malfunctioning
• Severe knee or hip problems
• Group with knee osteoarthritis:
• Systematic engagement in (resistance) exercise in the 12-months prior to participation
• Cardiovascular disease
• Neurological disorders
• Cognitive malfunctioning
• Severe hip problems

Sponsors & Collaborators

• KU Leuven: lead

Study Sites (1)

Department of Movement Sciences

Leuven, 3001, Belgium

Location

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr.

Study Record Dates

• First Submitted: September 18, 2018
• First Posted: September 21, 2018
• Study Start: September 1, 2018
• Primary Completion: December 20, 2018
• Study Completion: December 20, 2018
• Last Updated: February 8, 2019

Record last verified: 2019-02

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)