Thoracic Paravertebral Blocks Using a Combination of Ropivacaine and Dexmedetomidine

NCT03677115 | Withdrawn Phase 4 DMC

• 1 other identifier: 201707158
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators designed a study to assess whether thoracic paravertebral blocks using a combination of ropivacaine and dexmedetomidine prolong nerve block duration.

Conditions

Thoracic Paravertebral Blocks

Outcome Measures

Primary Outcomes (1)

• Change of analgesia duration

  Change of thoracic paravertebral block analgesia duration

  Change from Baseline to 3 days after surgery

Study Arms (1)

dexmedetomidine group

EXPERIMENTAL

a combination of ropivacaine and dexmedetomidine

Drug: Dexmedetomidine

Interventions

Dexmedetomidine DRUG

combination of ropivacaine and dexmedetomidine 20 ug every time

dexmedetomidine group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients were included in the study if they were ethnic Chinese,
• American Society of Anesthesiologists (ASA) physical status I or II,
• candidates for general anesthesia undergoing thoracic surgery

You may not qualify if:

• Patients were excluded if they do not want to cooperate with the test,
• had a history of radial artery puncture or coronary artery bypass grafting,
• had acute vessel trauma,or had been diagnosed with Raynaud' disease,
• had suffered from mental or neurological disorders

Sponsors & Collaborators

• China Medical University, China: lead

Study Sites (1)

the First Hospital of China Medical University

Shenyang, Liaoning, 110001, China

Location

MeSH Terms

Interventions

Dexmedetomidine

Intervention Hierarchy (Ancestors)

Imidazoles; Azoles; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds

Study Design

• Study Type: interventional
• Phase: phase 4
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: a single-dose thoracic paravertebral analgesia for postoperative pain control after thoracoscopic lobectomy

Study Record Dates

• First Submitted: September 16, 2018
• First Posted: September 19, 2018
• Study Start: November 1, 2018
• Primary Completion: March 30, 2023
• Study Completion: March 30, 2023
• Last Updated: November 12, 2021

Record last verified: 2021-11

Locations

CN (1)