Impact of Glaucoma and Visual Field Loss on Life Space

NCT03673644 | Active Not Recruiting

• 2 other identifiers: IRB-3000015525P30AG022838-14
• Study Type: observational
• Target: 88
• Locations: 1 country
• Sites: 1

Brief Summary

Mobility refers to a person's purposeful movement through the environment from one place to another and can be conceptualized as a continuum from bed bound (immobility) on one extreme to making excursions to distant locations on the other extreme. Primary open-angle glaucoma (POAG) is a chronic, progressive optic neuropathy that can lead to gradual loss of vision in the peripheral field and central vision. Older adults with POAG have an increased risk for motor vehicle collisions and falls. Moreover, existing studies suggest that patients with POAG exhibit more postural sway while standing as measured by a balance platform and also tend to walk more slowly than those who are normally sighted and free of ocular disease. While these disturbances likely influence mobility, there has been little research directly assessing the impact of POAG on mobility. This study will assess the impact of POAG on life space (one aspect of mobility) and will determine whether difficulties with life space are associated with difficulties experienced under conditions of dim lighting.

Conditions

Primary Open-angle Glaucoma

Outcome Measures

Primary Outcomes (1)

• Assessment of life space measured with the Life Space Questionnaire

  The Life Space Questionnaire is a 9-item questionnaire that assesses how much a person gets out and about and the spatial extent of the person's typical life space, i.e., what is the usual range of places in which the person engages in activities within the designated time frame. Patients are asked to respond either Yes or No.

  Day one

Secondary Outcomes (4)

• Relationship between the Life Space Questionnaire and vision loss

  Day one

• Assessment of vision under dim illumination and at night using the Low Luminance Questionnaire

  Day one

• Relationship between Low Luminance Questionnaire and vision loss

  Day one

• Relationship between the Low Luminance Questionnaire and the Life Space Questionnaire

  Day one

Study Arms (1)

Primary Open-Angle Glaucoma

Two following two questionnaires will be administered: 1. Life Space Questionnaire: This 9-item questionnaire is interested in finding out how much a person gets out and about and the spatial extent of the person's typical life space, i.e., what is the usual range of places in which the person engages in activities within the designated time frame. 2. Low Luminance Questionnaire: This 32-item questionnaire is interested in finding out problems that involve vision under different lighting conditions or feelings that people have about your vision under different lighting conditions.

Other: Questionnaires

Interventions

Questionnaires OTHER

Two questionnaires will be administered, one focusing on life space and the other focusing on low luminance.

Primary Open-Angle Glaucoma

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants that are enrolled in the Early Detection of Glaucoma Progression using a Novel Individualized Approach (IRB-300000301) or in the African Descent and Glaucoma Evaluation (ADAGES) IV: Alterations of the Lamina Cribrosa in Progression (IRB-161115004).

You may qualify if:

• Clinical diagnosis of primary open-angle glaucoma
• Best-corrected visual acuity of 20/40 or better
• Spherical refraction within ± 5 Diopters
• Cylinder refraction within ± 3 Diopters

You may not qualify if:

• History of intra-ocular surgery other than uncomplicated cataract or glaucoma surgery
• Significant cognitive impairment

Sponsors & Collaborators

• University of Alabama at Birmingham: lead
• National Institute on Aging (NIA): collaborator

Study Sites (1)

University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States

Location

MeSH Terms

Conditions

Glaucoma, Open-Angle

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Glaucoma; Ocular Hypertension; Eye Diseases

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Lyne Racette, PhD

  University of Alabama at Birmingham

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 11, 2018
• First Posted: September 17, 2018
• Study Start: October 9, 2018
• Primary Completion: May 30, 2019
• Study Completion (Estimated): May 30, 2026
• Last Updated: September 11, 2025

Record last verified: 2025-09

Locations

US (1)