NCT03672214

Brief Summary

The aim of this study is to compare the incidence of catheter associated culture-based urinary tract infection (UTI) after elective CD with or without preoperative placement of a urinary catheter.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
400

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jun 2019

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 13, 2018

Completed
1 day until next milestone

First Posted

Study publicly available on registry

September 14, 2018

Completed
9 months until next milestone

Study Start

First participant enrolled

June 1, 2019

Completed
4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2023

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2023

Completed
Last Updated

April 25, 2019

Status Verified

September 1, 2018

Enrollment Period

4 years

First QC Date

September 13, 2018

Last Update Submit

April 24, 2019

Conditions

Outcome Measures

Primary Outcomes (1)

  • The incidence of urinary tract infection (UTI).

    Urine culture (second day post partum) yielding ≥ 10\*5 CFU/ml (of one type of bacteria).

    3 days

Secondary Outcomes (7)

  • The incidence of UTI later than second day postpartum

    30 days

  • Any need for catheterization due to postoperative urinary retention

    24 hours

  • Postpartum blood loss >1000 mL.

    4 hours

  • Time to ambulation

    Up until 48 hours

  • Length of hospital stay

    Up until 7 days

  • +2 more secondary outcomes

Study Arms (2)

Without placement of a catheter

EXPERIMENTAL

No placement of indwelling catheter prior to Caesarean section

Procedure: Without placement of indwelling catheter

With placement of a catheter

ACTIVE COMPARATOR

Placement of indwelling catheter prior to Caesarean section

Procedure: With placement of indwelling catheter

Interventions

No placement of indwelling catheter prior to Caesarean section

Without placement of a catheter

Placement of indwelling catheter prior to Caesarean section

With placement of a catheter

Eligibility Criteria

Age18 Years+
Sexfemale(Gender-based eligibility)
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Elective caesarean section.

You may not qualify if:

  • Antibiotic therapy during the last week before caesarean section
  • ≥ 3 prior CDs.
  • Contractions or rupture of membranes.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

The Regional Hospital of Randers

Randers, 8930, Denmark

Location

Related Publications (9)

  • Abdel-Aleem H, Aboelnasr MF, Jayousi TM, Habib FA. Indwelling bladder catheterisation as part of intraoperative and postoperative care for caesarean section. Cochrane Database Syst Rev. 2014 Apr 11;2014(4):CD010322. doi: 10.1002/14651858.CD010322.pub2.

    PMID: 24729285BACKGROUND
  • Weber DJ, Sickbert-Bennett EE, Gould CV, Brown VM, Huslage K, Rutala WA. Incidence of catheter-associated and non-catheter-associated urinary tract infections in a healthcare system. Infect Control Hosp Epidemiol. 2011 Aug;32(8):822-3. doi: 10.1086/661107. No abstract available.

    PMID: 21768769BACKGROUND
  • Ghoreishi J. Indwelling urinary catheters in cesarean delivery. Int J Gynaecol Obstet. 2003 Dec;83(3):267-70. doi: 10.1016/s0020-7292(03)00144-9.

    PMID: 14643036BACKGROUND
  • Nasr AM, ElBigawy AF, Abdelamid AE, Al-Khulaidi S, Al-Inany HG, Sayed EH. Evaluation of the use vs nonuse of urinary catheterization during cesarean delivery: a prospective, multicenter, randomized controlled trial. J Perinatol. 2009 Jun;29(6):416-21. doi: 10.1038/jp.2009.4. Epub 2009 Feb 12.

    PMID: 19212327BACKGROUND
  • Senanayake H. Elective cesarean section without urethral catheterization. J Obstet Gynaecol Res. 2005 Feb;31(1):32-7. doi: 10.1111/j.1447-0756.2005.00237.x.

    PMID: 15669989BACKGROUND
  • Oliphant SS, Bochenska K, Tolge ME, Catov JM, Zyczynski HM. Maternal lower urinary tract injury at the time of Cesarean delivery. Int Urogynecol J. 2014 Dec;25(12):1709-14. doi: 10.1007/s00192-014-2446-2. Epub 2014 Jun 26.

    PMID: 24964762BACKGROUND
  • Phipps MG, Watabe B, Clemons JL, Weitzen S, Myers DL. Risk factors for bladder injury during cesarean delivery. Obstet Gynecol. 2005 Jan;105(1):156-60. doi: 10.1097/01.AOG.0000149150.93552.78.

    PMID: 15625157BACKGROUND
  • Hansen BS, Soreide E, Warland AM, Nilsen OB. Risk factors of post-operative urinary retention in hospitalised patients. Acta Anaesthesiol Scand. 2011 May;55(5):545-8. doi: 10.1111/j.1399-6576.2011.02416.x. Epub 2011 Mar 21.

    PMID: 21418152BACKGROUND
  • Mulder FE, Schoffelmeer MA, Hakvoort RA, Limpens J, Mol BW, van der Post JA, Roovers JP. Risk factors for postpartum urinary retention: a systematic review and meta-analysis. BJOG. 2012 Nov;119(12):1440-6. doi: 10.1111/j.1471-0528.2012.03459.x. Epub 2012 Aug 20.

    PMID: 22900796BACKGROUND

MeSH Terms

Conditions

Urinary Tract InfectionsInfections

Condition Hierarchy (Ancestors)

Urologic DiseasesFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesMale Urogenital Diseases

Study Officials

  • Pinar Bor, MD, Ph.D.

    Aarhus University and the Region Hospital of Randers

    STUDY CHAIR

Central Study Contacts

Helle F Bungum, MD

CONTACT

Pinar Bor, MD, Ph.D.

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 13, 2018

First Posted

September 14, 2018

Study Start

June 1, 2019

Primary Completion

June 1, 2023

Study Completion

November 1, 2023

Last Updated

April 25, 2019

Record last verified: 2018-09

Locations