Phase Contrast in Valvular Heart Disease

NCT03669666 | Completed

• 1 other identifier: PC-CMR-VHDs
• Study Type: observational
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

The ability to quantify flow directly using through-plane phase contrast velocity mapping is a unique advantage of cardiovascular magnetic resonance and does not rely on the calculation from complex equations as echocardiography. The aim s is to study the role of cardiac MRI in the evaluation of valvular heart disease through quantification of the impact of valvular lesions upon cardiac function by accurate estimation of the left ventricular ejection fraction

Conditions

Valvular Heart Disease (Aortic and Mitral Valves)

Keywords

valvular heart disease; ejection fraction

Outcome Measures

Primary Outcomes (1)

• measurement of ejection fraction

  measurement of ejection fraction via estimation of stroke volume divided by end diastolic volume of the left ventricle

  1 day

Study Arms (2)

control group

10 normal healthy subjects are conducted for cardiac magnetic resonance imaging examination

case group

25 patients with valvular heart disease diagnosed clinically and by echocardiography are conducted for cardiac magnetic resonance imaging examination

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study will be conducted on 35 subjects including 25 patients with reversed cardiac hemodynamics and 10 age- and sex-matched healthy adult controls with no clinically or echocardiographically detected cardiac abnormalities. The 25 patients have been diagnosed clinically and by echocardiography to have valvular heart disease of different aetiologies (14 rheumatics, 5 ischemic, 6 non-ischemic cardiomyopathies).

You may qualify if:

• Patients with clinically diagnosed valvular heart disease and confirmed by echocardiography

You may not qualify if:

• Patients with known contraindication to MRI including the presence of paramagnetic
• Surgical clips, or pacemakers
• Severely ill patients
• Claustrophobic or restless subjects
• Patients with arrhythmia

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

abdulrahman Emam

Asyut, 71111, Egypt

Location

Related Publications (5)

• Iung B, Baron G, Butchart EG, Delahaye F, Gohlke-Barwolf C, Levang OW, Tornos P, Vanoverschelde JL, Vermeer F, Boersma E, Ravaud P, Vahanian A. A prospective survey of patients with valvular heart disease in Europe: The Euro Heart Survey on Valvular Heart Disease. Eur Heart J. 2003 Jul;24(13):1231-43. doi: 10.1016/s0195-668x(03)00201-x.

  PMID: 12831818 BACKGROUND

• Maganti K, Rigolin VH, Sarano ME, Bonow RO. Valvular heart disease: diagnosis and management. Mayo Clin Proc. 2010 May;85(5):483-500. doi: 10.4065/mcp.2009.0706.

  PMID: 20435842 BACKGROUND

• Chambers JB, Myerson SG, Rajani R, Morgan-Hughes GJ, Dweck MR. Multimodality imaging in heart valve disease. Open Heart. 2016 Mar 8;3(1):e000330. doi: 10.1136/openhrt-2015-000330. eCollection 2016.

  PMID: 26977308 BACKGROUND

• Simpson IA, Sahn DJ. Quantification of valvular regurgitation by Doppler echocardiography. Circulation. 1991 Sep;84(3 Suppl):I188-92.

  PMID: 1884485 BACKGROUND

• Myerson SG. Heart valve disease: investigation by cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2012 Jan 19;14(1):7. doi: 10.1186/1532-429X-14-7.

  PMID: 22260363 BACKGROUND

MeSH Terms

Conditions

Heart Valve Diseases

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principal investigator

Study Record Dates

• First Submitted: September 12, 2018
• First Posted: September 13, 2018
• Study Start: July 1, 2017
• Primary Completion: June 30, 2018
• Study Completion: July 30, 2018
• Last Updated: September 13, 2018

Record last verified: 2018-09

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)