Influence of Platelet Concentrates on Wound Healing

NCT03667638 | Completed

• 1 other identifier: #1055-2011
• Study Type: interventional
• Target: 5
• Locations: 1 country
• Sites: 1

Brief Summary

Chronic soft tissues defects can extend into the fat layer or even deeper and can cause functional disadvantages. Split-thickness skin grafts (STSGs) used to cover these wounds have varying success rates. To improve wound healing in chronic wounds the authors have studied the application of autologous platelet concentrates in a human keratinocyte culture model in vitro and in a combination with surgical procedures in vivo as second line therapy in patients with initially failed wound closure.

Conditions

Platelet-Rich Plasma; Wound Healing Delayed

Keywords

Platelet-Rich Plasma; Laser Doppler Imaging; Growth Factors; Wound Healing; Chronic wound healing disorder; Wound quality of life

Outcome Measures

Primary Outcomes (1)

• Wound Closure

  Area of wound closure in % compared to initial size

  4 weeks

Secondary Outcomes (3)

• Blood Flow

  4 weeks

• Wound Quality of Life

  21 days

• Ease of surgical wound closure

  21 days

Study Arms (1)

PRP Intervention

EXPERIMENTAL

PRP injection into wound border

Combination Product: Platelet-Rich Plasma

Interventions

Platelet-Rich Plasma COMBINATION_PRODUCT

Adding PRP to wound bed during surgical debridement

Also known as: PRP, PMC

PRP Intervention

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• exposed tendons, ligaments or bone for \>3 weeks
• no healing tendency

You may not qualify if:

• sepsis
• intensive care treatment
• continuous smoking
• pregnancy or breast feeding women
• participants of other studies.

Sponsors & Collaborators

• Hannover Medical School: lead

Study Sites (1)

Medical School Hannover

Hanover, Lower Saxony, 30625, Germany

Location

Related Publications (39)

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  PMID: 36317012 DERIVED

Study Officials

• Peter Vogt, MD

  Medical School Hannover

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: September 9, 2018
• First Posted: September 12, 2018
• Study Start: November 1, 2016
• Primary Completion: November 1, 2017
• Study Completion: December 1, 2017
• Last Updated: September 12, 2018

Record last verified: 2018-09

Locations

DE (1)