Registry of Patients With Takotsubo Syndrome
NYU Takotsubo (Broken Heart Syndrome) Registry
1 other identifier
observational
500
1 country
1
Brief Summary
Takotsubo syndrome is a condition which mimics acute myocardial infarction, and is diagnosed in 1.5% to 2.2% of patients referred to hospital with suspected acute coronary syndrome. It is also known as broken heart syndrome, takotsubo cardiomyopathy, stress cardiomyopathy and apical ballooning cardiomyopathy, among other names. The pathogenesis of this disorder is not well understood. Possible mechanisms include catecholamine excess, coronary artery spasm, microvascular dysfunction, among others. This is a multicenter, nation-wide, observational study of patients who were previously diagnosed with takotsubo syndrome. The investigators aim to use this registry to help plan and carry out further studies and to improve understanding of the pathophysiologic mechanisms of this syndrome. In addition participants will be followed for events, and to monitor quality of life and stress.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2009
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 11, 2009
CompletedFirst Submitted
Initial submission to the registry
May 16, 2018
CompletedFirst Posted
Study publicly available on registry
September 10, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
August 1, 2029
December 30, 2025
December 1, 2025
19 years
May 16, 2018
December 23, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Major Adverse Cardiac Events
Medical record review and patient report of repeat takotsubo event, MI, heart failure, unstable angina, chest pain ER visit, cardiovascular death, stroke
up to 10 years
Secondary Outcomes (4)
Quality of life assessed using the Patient Reported Outcome Measurement Information System (PROMIS-10) questionnaire
every four months up to 10 years
Anxiety is assessed using the Hospital Anxiety and Depression Scale (HADS-A)
every four months up to 10 years
Depression assessed using the Patient Health Questionnaire (PHQ-9)
every four months up to 10 years
Perceived stress is measured using the Perceived Stress Scale (PSS-10)
every four months up to 10 years
Eligibility Criteria
Patients with history of takotsubo syndrome
You may qualify if:
- Physician diagnosis of takotsubo syndrome
- Age\>18 years
You may not qualify if:
- \- Lack of capacity to provide informed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
NYU School of Medicine
New York, New York, 10016, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 10 Years
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 16, 2018
First Posted
September 10, 2018
Study Start
September 11, 2009
Primary Completion (Estimated)
September 1, 2028
Study Completion (Estimated)
August 1, 2029
Last Updated
December 30, 2025
Record last verified: 2025-12