Strain Echocardiography During Septic Shock : an Observational Pilot Study
Sepsistrain
1 other identifier
observational
50
1 country
1
Brief Summary
The mortality of septic shock remains high nowadays despite a trend toward improvement.Septic cardiomyopathy has been reported in most experimental models of sepsis shock. Its relationship with mortality is unclear. A decrease in mortality have been reported in patients with decreased left ventricular ejection fraction (LVEF), but a recent meta-analysis did not support such results. In fact, it appears that high LVEF are linked to profound vasoplegia which is associated to bad outcome. In the other hand, alterations of Strain echocardiography, a new method allowing a more sensitive evaluation of heart function, have been associated with a worse outcome in sepsis patients. Only few studies have examined echocardiographic strain during sepsis shock in human, and its natural history was only described in pigs. Moreover, the right ventricular strain was reported only by Orde et al whereas the evolution of strain during fluid infusion have never been studied. The aim of the present study is to describe the natural history of echocardiographic strain during sepsis shock and to determine its prognosis value.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Feb 2016
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 22, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 31, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
March 31, 2018
CompletedFirst Submitted
Initial submission to the registry
April 5, 2018
CompletedFirst Posted
Study publicly available on registry
September 10, 2018
CompletedDecember 1, 2025
May 1, 2019
2.1 years
April 5, 2018
November 24, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Global peak systolic longitudinal strain assessed by echocardiography. Global peak systolic longitudinal strain
up to 90 days
Secondary Outcomes (1)
ICU mortality
up to 90 days
Interventions
strain echocardiography during septic shock
Eligibility Criteria
ICU patients
You may qualify if:
- Septic shock (suspected or proven infection and norepinephrine ≥ 0,25µg/kg/min)
You may not qualify if:
- Patient \< 18 year of age
- Pregnant women
- History of myocardial infarction, valvular disease, atrial fibrillation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Intensive care unit CHU Nimes
Nîmes, 30029, France
Related Publications (1)
Bazalgette F, Roger C, Louart B, Daurat A, Bobbia X, Lefrant JY, Muller L. Prognostic value and time course evolution left ventricular global longitudinal strain in septic shock: an exploratory prospective study. J Clin Monit Comput. 2021 Dec;35(6):1501-1510. doi: 10.1007/s10877-020-00620-w. Epub 2020 Nov 20.
PMID: 33216237RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Claire Roger, MD,PhD
CHU Nimes
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 5, 2018
First Posted
September 10, 2018
Study Start
February 22, 2016
Primary Completion
March 31, 2018
Study Completion
March 31, 2018
Last Updated
December 1, 2025
Record last verified: 2019-05