Serum Magnesium Level Administration in Severe Pre-eclampsia Obese Pregnancy
Serum Magnesium Level Between Administered Rate of 2 g/hr Versus 2.5 g/hr in Severe Pre-eclampsia Obese Pregnancy, Multicentered Randomized Study
1 other identifier
interventional
60
1 country
1
Brief Summary
Comparison of the magnesium level in difference continuous rate in women who were diagnosed severe pre-eclampsia obese
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Sep 2018
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 14, 2018
CompletedFirst Posted
Study publicly available on registry
September 7, 2018
CompletedStudy Start
First participant enrolled
September 30, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 30, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
May 31, 2019
CompletedOctober 12, 2020
September 1, 2018
3 months
May 14, 2018
October 8, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
therapeutic level
Serum magnesium level
4 hours after infusion magnesium sulfate
Secondary Outcomes (1)
Outcome of pregnancy
24 hours after delivery
Study Arms (2)
controlled group
EXPERIMENTALcontrolled group : administration of magnesium sulfate is 4 grams for loading dose in 15 minutes, followed by 2 grams for maintenance dose per hour
Experimental group
EXPERIMENTALgroup : administration of magnesium sulfate is 4 grams for loading dose in 15 minutes, followed by 2.5 grams for maintenance dose per hour
Interventions
controlled group : administration of magnesium sulfate is 4 grams for loading dose in 15 minutes, followed by 2 grams for maintenance dose per hour Experimental group : administration of magnesium sulfate is 4 grams for loading dose in 15 minutes, followed by 2.5 grams for maintenance dose per hour
Eligibility Criteria
You may qualify if:
- Pregnancy women who have MBI ≥ 31kg/m2
- Pregnancy women who were diagnosed severe pre-eclampsia at gestational age 24 weeks more.
- Pregnancy women who were diagnosed eclampsia at gestational age 24 weeks more.
You may not qualify if:
- Pregnancy women who were chronic kidney disease or have serum creatinine more than 1.1 mg/dl
- Pregnancy women who have contraindication to use magnesium sulfate
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Rajavithi Hospital
Bangkok, 10400, Thailand
Related Publications (1)
Diaz V, Long Q, Oladapo OT. Alternative magnesium sulphate regimens for women with pre-eclampsia and eclampsia. Cochrane Database Syst Rev. 2023 Oct 10;10(10):CD007388. doi: 10.1002/14651858.CD007388.pub3.
PMID: 37815037DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- FACTORIAL
- Sponsor Type
- OTHER GOV
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 14, 2018
First Posted
September 7, 2018
Study Start
September 30, 2018
Primary Completion
December 30, 2018
Study Completion
May 31, 2019
Last Updated
October 12, 2020
Record last verified: 2018-09