NCT03657706

Brief Summary

Several surgical techniques have been proposed to correct recession defect and attain root coverage. Though, the majority were executed on Miller Class I and II recession defects. Moreover, Analysis of literature revealed only a few studies that treated miller class III recession defects. In the current study, a new modification in the free gingival graft is proposed to provide the patient with more esthetic outcome, less pain and postoperative trauma. Likewise, the proposed graft modification will combined both FGG and CTG benefits, overcome the limitations of the FGG and enhances the advantages of CTG.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
22

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Jun 2018

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 15, 2018

Completed
11 days until next milestone

First Submitted

Initial submission to the registry

June 26, 2018

Completed
2 months until next milestone

First Posted

Study publicly available on registry

September 5, 2018

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2019

Completed
1.3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2020

Completed
Last Updated

September 5, 2018

Status Verified

September 1, 2018

Enrollment Period

12 months

First QC Date

June 26, 2018

Last Update Submit

September 4, 2018

Conditions

Outcome Measures

Primary Outcomes (1)

  • root coverage aesthetic score (RES)

    RES evaluated five variables 6 months: gingival margin (GM), marginal tissue contour (MTC), soft tissue texture (STT), MGJ alignment, and gingival color (GC). Zero, 3, or 6 points were used for the evaluation of the position of the gingival margin, whereas a score of 0 or 1 point was used for each of the other variables. The ideal esthetic score was 10. Zero points were assigned if the final position of the gingival margin was equal or apical to the previous recession depth (failure of root coverage procedure), irrespective of color, the presence of a scar, MTC, or MGJ. Zero points were also assigned when a partial or total loss of interproximal papilla (black triangle) occurred following the treatment

    6 months

Secondary Outcomes (1)

  • recession depth

    6 months

Study Arms (2)

group A

ACTIVE COMPARATOR

tunnel procedure with subepithelial connective tissue graft (sCTG)

Procedure: group A (Tunnel procedure with subepithelial connective tissue graft (sCTG)

group B

ACTIVE COMPARATOR

tunnel procedure with modified free gingival graft (mFGG)

Procedure: group B (Tunnel procedure with modified free gingival graft (mFGG))

Interventions

Subepithelial connective tissue graft (autogenous graft) will be harvested from the palate by Single incision technique to be used with the prepared tunnel to treating gingival recession

Also known as: Tunnel procedure with subepithelial connective tissue graft (sCTG), Autogenous sCTG will be used with tunnel procedure
group A

modified free gingival graft (autogenous graft) will be harvested from the palate and will be used with the prepared tunnel to be used in treating gingival recession

Also known as: Tunnel procedure with modified free gingival graft (mFGG), Autogenous mFGG will be used with tunnel procedure
group B

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Patients with healthy systemic condition.
  • Buccal recession defects classified as Miller class III.
  • Clinical indication and/or patient request for recession coverage.
  • O'Leary index less than 20%.

You may not qualify if:

  • Pregnant females.
  • Smokers as smoking is a contraindication for any plastic periodontal surgery.
  • Unmotivated, uncooperative patients with poor oral hygiene
  • Patients with habits that may compromise the longevity and affect the result of the study as alcoholism or para-functional habits.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Cairo university

Giza, Egypt

Location

MeSH Terms

Conditions

Gingival Recession

Interventions

N-(N-(4-deoxy-4-amino-10-methylpteroyl)-4-fluoroglutamyl)-gamma-glutamate

Condition Hierarchy (Ancestors)

Gingival DiseasesPeriodontal DiseasesMouth DiseasesStomatognathic DiseasesPeriodontal Atrophy

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principle investigator

Study Record Dates

First Submitted

June 26, 2018

First Posted

September 5, 2018

Study Start

June 15, 2018

Primary Completion

June 1, 2019

Study Completion

October 1, 2020

Last Updated

September 5, 2018

Record last verified: 2018-09

Locations