Metabolomic Alterations in the Vascular Compartment in Patients With Sepsis

NCT03655899 | Terminated

• 1 other identifier: Metabolomics 16024946
• Study Type: observational
• Target: 37
• Locations: 1 country
• Sites: 1

Brief Summary

This study will investigate the metabolic alterations of vascular cells caused by sepsis and septic shock

Conditions

Endothelial Dysfunction

Keywords

metabolomics; systems biology; Sepsis

Outcome Measures

Primary Outcomes (1)

• Shock induced endotheliopaty

  Mortality

  Up to 30 days

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with sepsis or septic shock

You may qualify if:

• year or older
• Sepsis or Septic shock

You may not qualify if:

• Pregnant or breastfeeding
• Hemoglobin ≤ 5.0 mmol/L
• Platelets ≤ 5.0 mia/L
• Consent not obtainable
• Do not resuscitate order

Sponsors & Collaborators

• Pär Johansson: lead

Study Sites (1)

Bispebjerg Hospital

Copenhagen, Copenhagen NV, DK-2400, Denmark

Location

Biospecimen

Retention: SAMPLES WITH DNA

Red blood cells, white blood cells, platelets, plasma

MeSH Terms

Conditions

Sepsis

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Pär Johansson

  Rigshospitalet, Dept. of Clinical Immunology

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 26, 2017
• First Posted: August 31, 2018
• Study Start: October 23, 2017
• Primary Completion: March 12, 2019
• Study Completion: March 12, 2019
• Last Updated: September 12, 2019

Record last verified: 2019-09

Locations

DK (1)