Impact of Sleep Apnea on Sepsis Mortality
The Impact of Sleep Apnea on the Mortality of Sepsis - A Retrospective Study
1 other identifier
observational
280
1 country
1
Brief Summary
By clinical record review, this retrospective study aims to compare the mortality of sepsis patients with versus without obstructive sleep apnea, who were diagnosed and treated in Taipei Veterans General Hospital, Taiwan.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started May 2018
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 28, 2018
CompletedFirst Submitted
Initial submission to the registry
July 24, 2018
CompletedFirst Posted
Study publicly available on registry
August 31, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 27, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
May 27, 2019
CompletedMay 16, 2019
May 1, 2019
12 months
July 24, 2018
May 14, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Mortality
percentage of sepsis patients died of sepsis
up to 40 days
Secondary Outcomes (3)
Survival time
up to 40 days
Mortality
7-day
Mortality
28-day
Study Arms (2)
Sepsis patients with OSA
Sepsis patients who received a prior polysomnography showing an apnea-hypopnea index at least 5/hr with compatible symptoms
Sepsis patients without OSA
Sepsis patients who received a prior polysomnography showing an apnea-hypopnea index less than 5/hr
Interventions
The diagnosis of OSA (obstructive sleep apnea) relies on polysomnographic data showing an apnea-hypopnea index at least 5/hr with compatible symptoms.
Eligibility Criteria
Sepsis Patients who had received a polysomnography at Taipei Veterans General Hospital during Jan. 1, 2001 to May 31, 2017 will be enrolled.
You may qualify if:
- Patients who received received a polysomnography at Taipei Veterans General Hospital during Jan. 1, 2001 to May 31, 2017
- Patients who were admitted with a diagnosis of sepsis after the polysomnography
- The diagnosis of sepsis fulfilling the clinical criteria
You may not qualify if:
- Younger than 20 years
- Not compatible with a definition of sepsis
- subjects with incomplete data
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Taipei Veterans General Hospital
Taipei, 112, Taiwan
Related Publications (2)
Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G; SCCM/ESICM/ACCP/ATS/SIS. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003 Apr;31(4):1250-6. doi: 10.1097/01.CCM.0000050454.01978.3B.
PMID: 12682500BACKGROUNDHuang CY, Chen YT, Wu LA, Liu CJ, Chang SC, Perng DW, Chen YM, Chen TJ, Lee YC, Chou KT. Sleep apnoea patients have higher mortality when confronting sepsis. Eur J Clin Invest. 2014 Jan;44(1):38-45. doi: 10.1111/eci.12187. Epub 2013 Nov 11.
PMID: 24117403RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Kun-Ta Chou, M.D
Taipei Veterans General Hospital, Taiwan
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER GOV
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
July 24, 2018
First Posted
August 31, 2018
Study Start
May 28, 2018
Primary Completion
May 27, 2019
Study Completion
May 27, 2019
Last Updated
May 16, 2019
Record last verified: 2019-05