Drug Resistance Among Asymptomatic Infection
Assessment of Drug Resistance Molecular Markers in Asymptomatic Malaria Among Migrant Workers in Myanmar
1 other identifier
observational
765
1 country
1
Brief Summary
A cross-sectional study will be conducted in selected 2 sentinel sites for assessment of drug resistance falciparum and vivax among asymptomatic infection in migrant workers in Myanmar.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2019
1 active site
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Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 23, 2018
CompletedFirst Posted
Study publicly available on registry
August 27, 2018
CompletedStudy Start
First participant enrolled
January 12, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 30, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
May 20, 2020
CompletedJuly 22, 2020
July 1, 2020
12 months
August 23, 2018
July 21, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Prevalence of the asymptomatic infection among the study population
Number of the hidden malaria cases by RDT, microscopy or nested PCR (molecular method)
1 week
Proportion of the drug resistance molecular markers among asymptomatic infections
Among the asymptomatic cases, molecular markers will be analyzed (K13 and pfmdr1 copy number for falciparum and pvcrt-o, pvmdr1, pvdhps and pvdhfr gene analysis for vivax cases by Sanger Sequencing.
3 months
Study Arms (2)
Shwegyin
Shwehyin is a Township in Bago Region. We will use the comparison between the two sentinel sites by the name of Shwegyin and Pinlebu. We will compare the prevalence of asymptomatic infection between these two sites. Then proportion of the drug resistance molecular markers will be compared.
Pinlebu
Pinlebu is a township in Sagaing Region. We will use the comparison between the two sentinel sites by the name of Shwegyin and Pinlebu. We will compare the prevalence of asymptomatic infection between these two sites. Then proportion of the drug resistance molecular markers will be compared.
Interventions
Proportion of the drug resistance molecular markers will be found-out and compared.
Eligibility Criteria
The activity will cover the migrant population of the Shwegyin Township (Bago Region) and Pinlebu Township (Sagaing Region).
You may qualify if:
- Age above 6 year
- Migrant population (moving from their normal residence place and working at a new place such as forest related activities, gold-mines or plantation sites for more than 3 months- 3 years)
- Both sex
- Participant who give informed-consent to participate the study
You may not qualify if:
- Known clinical malaria cases regardless of the species detected
- Patients with clinical symptoms of malaria at the time of examination
- Known history of malaria within 14 days
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Dr. Myat Phone Kyaw
Yangon, 11191, Burma
Biospecimen
The DNA samples will be kept at -80 degree C according to the consent of the participants. The samples will be kept with code number and limited restricted for use in future research.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Myat H Nyunt, PhD
Department of Medical Research
Study Design
- Study Type
- observational
- Observational Model
- ECOLOGIC OR COMMUNITY
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
August 23, 2018
First Posted
August 27, 2018
Study Start
January 12, 2019
Primary Completion
December 30, 2019
Study Completion
May 20, 2020
Last Updated
July 22, 2020
Record last verified: 2020-07