NCT03645577

Brief Summary

To determine the most frequent complication associated with cryoballoon PVI. The main hypothesis is to explore the incidence of phrenic nerve palsy.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
731

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jul 2018

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 24, 2018

Completed
2 days until next milestone

First Submitted

Initial submission to the registry

July 26, 2018

Completed
29 days until next milestone

First Posted

Study publicly available on registry

August 24, 2018

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 30, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 30, 2019

Completed
Last Updated

January 29, 2021

Status Verified

January 1, 2021

Enrollment Period

1.4 years

First QC Date

July 26, 2018

Last Update Submit

January 28, 2021

Conditions

Keywords

Pulmonary vein isolationPhrenic nerve palsyParoxysmal atrial fibrillationPersistent atrial fibrillation

Outcome Measures

Primary Outcomes (1)

  • Incidence of phrenic nerve palsy

    The overall incidence of phrenic nerve palsy during second and third Generation Cryoballoon based PVI will be evaluated.

    06/2012 until 04/2018

Secondary Outcomes (2)

  • Predictors of phrenic nerve palsy

    06/2012 until 04/2018

  • Clinical course of phrenic nerve palsy

    06/2012 until 04/2018

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

All patients who underwent a PVI by the second generation Cryoballoon.

You may qualify if:

  • age 18 years or older
  • Cryoballoon PVI
  • Periprocedural phrenic lesion

You may not qualify if:

  • \- Non

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Heart Center Luebeck, Electrophysiology

Lübeck, Germany

Location

Related Publications (2)

  • Heeger CH, Popescu SS, Sohns C, Pott A, Metzner A, Inaba O, Straube F, Kuniss M, Aryana A, Miyazaki S, Cay S, Ehrlich JR, El-Battrawy I, Martinek M, Saguner AM, Tscholl V, Yalin K, Lyan E, Su W, Papiashvili G, Botros MSN, Gasperetti A, Proietti R, Wissner E, Scherr D, Kamioka M, Makimoto H, Urushida T, Aksu T, Chun JKR, Aytemir K, Jedrzejczyk-Patej E, Kuck KH, Dahme T, Steven D, Sommer P, Tilz RR. Impact of cryoballoon application abortion due to phrenic nerve injury on reconnection rates: a YETI subgroup analysis. Europace. 2023 Feb 16;25(2):374-381. doi: 10.1093/europace/euac212.

  • Heeger CH, Sohns C, Pott A, Metzner A, Inaba O, Straube F, Kuniss M, Aryana A, Miyazaki S, Cay S, Ehrlich JR, El-Battrawy I, Martinek M, Saguner AM, Tscholl V, Yalin K, Lyan E, Su W, Papiashvili G, Botros MSN, Gasperetti A, Proietti R, Wissner E, Scherr D, Kamioka M, Makimoto H, Urushida T, Aksu T, Chun JKR, Aytemir K, Jedrzejczyk-Patej E, Kuck KH, Dahme T, Steven D, Sommer P, Richard Tilz R. Phrenic Nerve Injury During Cryoballoon-Based Pulmonary Vein Isolation: Results of the Worldwide YETI Registry. Circ Arrhythm Electrophysiol. 2022 Jan;15(1):e010516. doi: 10.1161/CIRCEP.121.010516. Epub 2021 Dec 28.

MeSH Terms

Conditions

Atrial Fibrillation

Condition Hierarchy (Ancestors)

Arrhythmias, CardiacHeart DiseasesCardiovascular DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
PI

Study Record Dates

First Submitted

July 26, 2018

First Posted

August 24, 2018

Study Start

July 24, 2018

Primary Completion

November 30, 2019

Study Completion

November 30, 2019

Last Updated

January 29, 2021

Record last verified: 2021-01

Locations