Atlas of Human Cognition by SEEG (MAPCOG-SEEG)
MAPCOG-SEEG
2 other identifiers
observational
200
1 country
4
Brief Summary
The main objective of MAPCOG\_SEEG is to create a database including brain recordings of cognition performed in clinical routine in patients during the pre-surgical SEEG assessment. This aims to be able to propose the first atlas of human cognition with a high temporal and spatial resolution.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Apr 2018
Longer than P75 for all trials
4 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 5, 2018
CompletedFirst Submitted
Initial submission to the registry
April 9, 2018
CompletedFirst Posted
Study publicly available on registry
August 23, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
September 1, 2030
March 19, 2024
March 1, 2024
9.9 years
April 9, 2018
March 18, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
SEEG recordings using functional brain mapping procedure (composite measures)
Prospective collection of data from SEEG recordings using functional brain mapping procedure performed in clinical routine during the presurgical assessment of patients with drug-resistant epilepsy. These data are represented by the electroencephalographic activity during the realization of the different cognitive tasks proposed to the patients. Electroencephalographic activity will then be analyzed in terms of Dynamic Spectral Imaging and in terms of high frequency activity (\[50-150Hz\]).
3 weeks
Secondary Outcomes (1)
Behavioral data (composite measures)
3 weeks
Study Arms (1)
SEEG Group
Group with SEEG analysis (Pre-surgical SEEG assessment)
Interventions
Visual and quantitative SEEG signal analysis. As available, collection of behavioral and neuropsychological postsurgical data
Eligibility Criteria
Adult (Age between 18 and 65 years) patients receiving an SEEG exploration for presurgical evaluation of focal refractory epilepsy
You may qualify if:
- Drug-resistant focal epilepsy
- Justified SEEG exploration in the context of presurgical assessment of epilepsy
- Written non-opposition to study participation
- Intellectual capacities compatible with the compliance in the cognitive tasks
You may not qualify if:
- Major Patient undergoing a legal protection measure or patient deprived of liberty as a result of a judicial or administrative decision
- Impossibility of collecting information on exposure (recent arrival in France, foreign language, etc.)
- Pregnant women (Contraindication to SEEG exploration)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (4)
University Hospital, Grenoble
Grenoble, 38043, France
CHRU Nancy
Nancy, France
Hôpital Ste Anne
Paris, 75014, France
CHU Rennes
Rennes, France
Related Publications (6)
Lachaux JP, Axmacher N, Mormann F, Halgren E, Crone NE. High-frequency neural activity and human cognition: past, present and possible future of intracranial EEG research. Prog Neurobiol. 2012 Sep;98(3):279-301. doi: 10.1016/j.pneurobio.2012.06.008. Epub 2012 Jun 26.
PMID: 22750156BACKGROUNDBaciu M, Perrone-Bertolotti M. What do patients with epilepsy tell us about language dynamics? A review of fMRI studies. Rev Neurosci. 2015;26(3):323-41. doi: 10.1515/revneuro-2014-0074.
PMID: 25741734RESULTCombrisson E, Perrone-Bertolotti M, Soto JL, Alamian G, Kahane P, Lachaux JP, Guillot A, Jerbi K. From intentions to actions: Neural oscillations encode motor processes through phase, amplitude and phase-amplitude coupling. Neuroimage. 2017 Feb 15;147:473-487. doi: 10.1016/j.neuroimage.2016.11.042. Epub 2016 Nov 30.
PMID: 27915117RESULTOssandon T, Vidal JR, Ciumas C, Jerbi K, Hamame CM, Dalal SS, Bertrand O, Minotti L, Kahane P, Lachaux JP. Efficient "pop-out" visual search elicits sustained broadband gamma activity in the dorsal attention network. J Neurosci. 2012 Mar 7;32(10):3414-21. doi: 10.1523/JNEUROSCI.6048-11.2012.
PMID: 22399764RESULTPerrone-Bertolotti M, Vidal JR, de Palma L, Hamame CM, Ossandon T, Kahane P, Minotti L, Bertrand O, Lachaux JP. Turning visual shapes into sounds: early stages of reading acquisition revealed in the ventral occipitotemporal cortex. Neuroimage. 2014 Apr 15;90:298-307. doi: 10.1016/j.neuroimage.2013.12.027. Epub 2013 Dec 24.
PMID: 24370818RESULTPerrone-Bertolotti M, Kujala J, Vidal JR, Hamame CM, Ossandon T, Bertrand O, Minotti L, Kahane P, Jerbi K, Lachaux JP. How silent is silent reading? Intracerebral evidence for top-down activation of temporal voice areas during reading. J Neurosci. 2012 Dec 5;32(49):17554-62. doi: 10.1523/JNEUROSCI.2982-12.2012.
PMID: 23223279RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Philippe Kahane, MD/PhD
University Hospital, Grenoble
- STUDY CHAIR
Marcela Perrone-Bertolotti, PhD
Centre National de la Recherche Scientifique, France
Central Study Contacts
Marcela Perrone-Bertolotti, PhD
CONTACT
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 9, 2018
First Posted
August 23, 2018
Study Start
April 5, 2018
Primary Completion (Estimated)
March 1, 2028
Study Completion (Estimated)
September 1, 2030
Last Updated
March 19, 2024
Record last verified: 2024-03