Study Stopped
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Computerized Cognitive Training for Patients With Epilepsy
1 other identifier
interventional
N/A
1 country
1
Brief Summary
This is a study on the effectiveness of computerized cognitive training for treatment of memory disorders in patients with epilepsy. Participants will be recruited from patients referred for neuropsychological assessment through the NYU Comprehensive Epilepsy Center's inpatient and outpatient services. Individuals meeting inclusion criteria will be screened for the presence of memory disturbance (defined by results of neuropsychological testing) and lack of exposure to any previous form of computerized cognitive training. All eligible subjects will be provided with an account for Lumosity with instructions to complete training modules 5 days per week for a total of 8 consecutive weeks. Outcomes will be evaluated through changes on the neuropsychological test battery.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
Started Dec 2020
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 21, 2018
CompletedFirst Posted
Study publicly available on registry
August 23, 2018
CompletedStudy Start
First participant enrolled
December 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 30, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
April 30, 2021
CompletedJuly 1, 2021
June 1, 2021
5 months
August 21, 2018
June 29, 2021
Conditions
Outcome Measures
Primary Outcomes (2)
Immediate Memory Index Score
Score on the Repeatable Battery for the Assessment of Neuro-psychological Status (RBANS) will be used to measure immediate memory
12 Months
Delayed Memory Index Score
Score on the Repeatable Battery for the Assessment of Neuro-psychological Status (RBANS) will be used to measure immediate memory
12 Months
Study Arms (1)
Epilepsy Patients
EXPERIMENTALInterventions
Working memory task that has users indicate whether the current symbol matches the one presented 2 symbols previously. As the user makes correct responses, the previous symbols reduce in contrast and fade int the background, ultimately disappearing, forcing the user to rely entirely on working memory to achieve success
The purpose id to remember the location of squares on a grid
The purpose is to create associations between visual and verbal information
The purpose is to decide whether or not cards with numbers and letters are either even or vowels. This measures inhibition, flexibility, and monitoring response set. Also, letterfluency, category fluency, and category switching.
The purpose is to visually scan several different objects and find the different object in array of pictures. This measures selective attention.
The purpose is to decide what suffix to use in order to complete a word whena prefix is given. The subject needs to come up with he ending of three different prefixes to complete the word. This task measures verbal modality, deductive reasoning, integration of multiple bits of information, and flexibility of thinking.
The purpose is to identify whether colors and words match each other. This measures the ability to inhibit a dominant and automatic verbal response
Identify which direction leaves are pointing or moving depending on their color.This measures inhibition of impulsive and perseverative responding, and the ability to establish and maintain instructional set.
purpose is to problem solve quantitative reasoningequationsand to decide which card is greater or if the 2 cards are equal when the math problem is solved.
The purposeis to remember the path a red frog takes as it jump from lilypad to lily pad in a pond. This measures flexibility of thinking on a visual-motor sequencing task and working memory
purpose is to guide specific colored trains into corresponding colored matching houses by attending to the different tracks. This measures divided attention.
Eligibility Criteria
You may qualify if:
- Documented diagnosis of epilepsy based on medical records. The records will be reviewed by the PI and the approved study personnel to confirm that a diagnosis of epilepsy has been made.
- Presence of memory disturbance, as defined by an immediate or delayed memory index score \< 85 on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)
- Availability of a home computer and internet for access to the computer training program.
You may not qualify if:
- Full Scale IQ \< 80, as assessed by an appropriate Wechsler scale (WAIS-IV or WASI-II).
- Epilepsy surgery within 8 weeks of the beginning of the trial.
- History of chronic progressive neurologic or neurodegenerative illnesses (e.g., Alzheimer's disease, multiple sclerosis, primary or metastatic malignancy). Patients with headache or migraine are not excluded.
- History of Axis I psychiatric illness with psychotic features. (e.g., schizophrenia or bipolar disorder). Patients with depression or anxiety (treated or untreated) without psychotic features are not excluded.
- Visual or auditory impairment, which precludes participation in part, or all of the testing or computer training.
- English as a first language will not be required, but participants must have either received some of their schooling in English or used English in their work for \>10 years.
- Previous exposure (\> one week) to Lumosity or a similar computerized training program.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
New York University School of Medicine
New York, New York, 10016, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
William Barr, MD
NYU Langone Health
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 21, 2018
First Posted
August 23, 2018
Study Start
December 1, 2020
Primary Completion
April 30, 2021
Study Completion
April 30, 2021
Last Updated
July 1, 2021
Record last verified: 2021-06
Data Sharing
- IPD Sharing
- Will not share